Huawei Technologies Co., Limited

Carl Zeiss Microscopy Gmbh

Chinese Academy of Sciences

Genentech, Inc.

Coupang, Corporation

Ii-vi Delaware, Inc.

The Hillman Group, Inc.

Other

Intel Corporation

General Electric Company

Sap Se

Dow Global Technolgoies LLC

Finisar Corporation

Ge Precision Healthcare LLC

Shanghai Jiaotong University

Jing Li

Xueli Ma

Christopher Matthew Weed

James Blake Fievet

Mark Lee Butts

Zongjie Wang

Jarrod Thomas Streng

Shuju Fan

Chuanfeng He

Fang Dong

Jie Ma

Yong Sen Zheng

Martin Stohr

Ilka Schlesiger

Michael Winterot

Qian Zhu

Leander Dietzsch

Rongting Gu

Hua Wen

Hong Tao Liu

Hualiang Jiang

Yang Zhang

Haiming Zhang

Hans Iding

Kaixian Chen

Wei Gu

Xin Xie

Jeffrey Stults

Ying Chen

Huade Shu

Ming Xu

Kun Yan

Xin Linghu

Qiangang Zheng

Youchu Wang

Bo Yang

Yu Chen Zhou

Xiaoxiao Zheng

Lei Li

Yongqiang Gao

Yi Zhou

Zeng Li

Qinglong Zeng

Zhuozhi Wang

Jianqing Xu

Leo Yu-yu Lin

Xiaofei Ma

Tingwei Xu

Puhui Miao

Vincent J Zimmer

Jian Li

Jun Chen

Lei Shi

Rajen M Patel

Hongyu Chen

Yunfeng Sun

Fei Li

Chao Yan

Jian Ding

Thomas Kwok-Fah Foo

Brian David Yanoff

Willard M Wiseman

Yi Chen

Jingjing Liu

Morgan Mark Hughes

Zhiwei Zhang

Liang Wu

Wenqing Peng

Lin Zhang

Yan Liu

Tao Jiang

Feng Gao

Fei Zhao

Yong Chen

Xin Jiang

Yueying Zhao

Xiao Bing Yun

Liping Zheng

Desmond Teck Beng Yeo

Xi Zhang

Vinay Verma

Jun Xiao

Tingting Song

Zhaoping Wu

Xiang Wang

Li Wan

Chen Zhou

Huan Zhou

Wanbin Zhang

Kun Tao

Xiaobing Yun

Chunhui Le

Chunhao Yang

Linghua Meng

Yangsheng Qiu

Dong Dong Yao

Liumeng Yang

Yongtang Zheng

Cun Tan

Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.

Spiro aromatic ring compound and use thereof

A data fusion method and apparatus, and a device and a storage medium are provided. The method includes: acquiring, from a first data center, a plurality of pieces of first data to be compared that are within a preset time period, and acquiring, from a second data center, a plurality of pieces of second data to be compared that are within the preset time period; then, determining the same data unique identifier in the plurality of pieces of first data to be compared and the plurality of pieces of second data to be compared, and taking the same data unique identifier as a first data identifier; and acquiring first data to be compared that corresponds to the first data identifier, and acquiring second data to be compared that corresponds to the first data identifier.

Data fusion method and apparatus, and device and storage medium

The disclosure relates to a light shielding device for a microscope and a microscope including the same. In the microscope, transmitting illumination light from a transmitting illumination light source is irradiated from above a stage to a specimen on the stage and fluorescent illumination light from a fluorescent illumination light source is irradiated from below the stage to the specimen on the stage. The light shielding device may be mounted to a lower end portion of a condenser of the microscope to at least partially block ambient light entering an objective of the microscope. The light shielding device may include a light shield and a mounting mechanism configured to mount the light shield below the lower end portion of the condenser in a manually removable manner, and/or the light shield includes a through hole and a light shielding portion surrounding the through hole.

Light shielding device for microscope and microscope comprising the same

Provided are anti-CD47 antibodies, the nucleic acid molecules encoding the anti-CD47 antibodies, expression vectors and host cells used for the expression of anti-CD47 antibodies. Provided are methods for validating the function of antibodies. The antibodies provide a potent agent for the treatment of cancers via modulating immune functions.

Anti-CD47 antibodies and uses thereof

Disclosed are a fault diagnosis circuit, method and apparatus, and computer readable storage medium. The fault diagnosis circuit includes a safety protection circuit electrically connected to a protected circuit and a diagnosis module electrically connected to the safety protection circuit. The safety protection circuit is configured to perform check operation on stored data in the protected circuit to obtain first check data, perform error injection on second check data corresponding to the stored data, and generate a first check result signal based on the first check data and the second check data after the error injection. The diagnosis module is configured to diagnose faults in the safety protection circuit based on the first check result signal. From embodiments of this disclosure, the safety protection circuit is diagnosed faults through a simple hardware structure, to eliminate the faults based on a diagnosis result, thereby ensuring normal operation of a chip.

Circuit, method, and apparatus for diagnosing a fault, and computer readable storage medium

Reinforcing seam for a bag or the like

Microscope

Glove

Provided are novel fully human monoclonal antibodies that bind to human LAG-3. It also provides the methods of hybridoma generation using humanized rats, the nucleic acid molecules encoding the anti-LAG-3 antibodies, expression vectors and host cells used for the expression of anti-LAG-3 antibodies. The invention further provides the methods for validating the function of antibodies in vitro. The antibodies of invention provide a potent agent for the treatment of multiple cancers via modulating human immune function.

Monoclonal antibody against human LAG-3, method for preparing the same, and use thereof

The present disclosure provides anti-TIM-3 antibodies or antigen-binding fragments thereof, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the uses thereof.

Anti-TIM-3 antibodies

The present disclosure provides a printed circuit board and a wire arrangement method thereof. The printed circuit board includes a packaged chip and at least two connectors, wires of the packaged chip that are connected to different connectors are distributed on different board layers; and when the packaged chip is connected to one of the connectors, a via is backdrilled to form a high-speed path from the packaged chip to the connector, and copper walls of board layers corresponding to other connectors are drilled out. The wires of the packaged chip that are connected to different connectors are distributed on different board layers. When the packaged chip is connected to one of the connectors, according to backdrilling of different depths, the via is backdrilled to form a high-speed path from the packaged chip to the connector, and copper walls of board layers corresponding to other connectors are drilled out.

Printed circuit board and wire arrangement method thereof

A low-temperature continuous-flow preparation method of bedaquiline includes the following steps. (a) A first feed liquid and a second feed liquid are subjected to a first continuous flow reaction for 30-600 seconds to obtain a first reaction mixture. (b) The first reaction mixture and a third feed liquid are subjected to a second continuous flow reaction for 30-600 seconds to obtain a second reaction mixture. (c) The second reaction mixture was quenched to afford bedaquiline.

Low-temperature continuous-flow preparation method of bedaquiline

Growing community of inventors

Shanghai, China

Jing Li