International Business Machines Corporation

Boe Technology Group Co., Ltd.

Beijing Boe Optoelectronics Technology Co., Ltd.

Chinese Academy of Sciences

Hefei Xinsheng Optoelectronics Technology Co., Ltd.

Siemens Aktiengesellschaft

University of Texas System

Other

Lenovo (beijing) Limited

Microsoft Technology Licensing, LLC

The Procter Gamble Company

Tsinghua University

Purdue Research Foundation

Chengdu Boe Optoelectronics Technology Co., Ltd.

Ca, Inc.

Jing Li

Jian Wang

Dan Wang

Peng Hui Jiang

Bin Xu

Ke Fei Wang

Fei Wang

Wei Li

Xiaochuan Chen

Wei Wang

Rui Li Xu

Jun Zhu

Xue Dong

Haisheng Wang

Lei Wang

Yingming Liu

Shengji Yang

Jing Wang

Peng Liu

Hao Liu

Lijun Sun

Yan Wang

Liang Zhang

Ying Liu

Xiao Ling Chen

Lei Liu

Zhiqiang Chen

Yan Li

Xin Wang

Wei Sun

Yu Wang

Li Wang

Fan Yang

Rui Fan

Meng Li

Ying Wang

Hao Sun

Weijie Zhao

Xin Zhang

Qi Cheng Li

Jie Ma

Jiantao Liu

Ping Wang

Wei Wei

Liang Li

Zheng Wang

Tao N Zhang

Dacheng Zhang

Guo Tong Xie

Zhiwei Wang

Guang Han Sui

Shi Lei Zhang

Jian Min Jiang

Feng Gao

Zhenyu Xie

Xu Chen

Jing Zhao

Yan Zhang

Heng Wang

Wen Sun

Chao Yang

Yue Liu

Tiansheng Li

Ning Wang

Chen Liu

Dong Hui Liu

Haifeng Xu

Wei Zheng

Li He

Bo Li

Kejun Kang

Hao Wu

Chen Chen

Hongmin Li

Yu Chen

Dawei Wang

Jianfeng Liu

Ruijun Dong

Fang Liu

Chen Zhao

Wei Wu

Yingzi Wang

Ke Zhao Li

Xuefeng Wang

Yuxiang Xing

Jian Wu

Gang Chen

Li Jun Mei

Xing Xing Wang

Xiaoye Ma

Jingbo Xu

Zhong Xian Li

Xiao Dong Li

Ting Li

Jiaxiang Zhang

Feng Yang

Li Zhang

John Geoffrey Chan

Shuang Zhang

The present invention falls within the field of biological medicine, and specifically relates to a method for preventing, alleviating and/or treating fatty liver disease and/or steatohepatitis. The method comprises administering, to an individual in need thereof, an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt, an ester, a stereoisomer, a polymorph, a solvate, an N-oxide, an isotopically labeled compound, a metabolite or a prodrug thereof.

Method for treating fatty liver disease and/or steatohepatitis

A processor obtains a pair including a question and an answer in natural language; determines at least one entity in the question and an entity type of each of the at least one entity consistent with the schema of a knowledge graph (KG); identifies a subset of candidate query templates based on the entity type of each of the at least one entity, wherein the candidate query templates are generated based on the schema of the KG; composes a set of queries by populating the at least one entity into each of the subset of candidate query templates; executes the set of queries on the KG to generate respective answers; identifies a first answer from the respective answers that is matching with the answer in the pair; and determines a candidate query template, from the subset of candidate query templates, corresponding to the first answer as a query template.

Generation of query templates for knowledge-graph based question answering system

Disclosed herein is a tricyclic compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.

Tricyclic compounds as HPK1 inhibitor and the use thereof

Disclosed herein is a compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.

Pyrrolo[2,3-b]pyrazines as HPK1 inhibitor and the use thereof

An analyzer and a control method thereof, a detection system, and a storage medium are provided. The control method of the analyzer includes: determining whether the analyzer obtains an analysis parameter corresponding to a detection chip used for detection; requesting and obtaining the analysis parameter in a case of being determined that the analyzer does not obtain the analysis parameter; and performing detection on the detection chip and analyzing a substance to be analyzed contained in the detection chip by using the analysis parameter to obtain analysis data of the substance to be analyzed in a case of being determined that the analyzer obtains the analysis parameter.

Analyzer and control method to obtain analysis data of a substance

A photoelectric detection device, including: a vacuum sealed housing, wherein the vacuum sealed housing includes a mounting interface for mounting the photodetector array so as to form a sealed space; the photodetector array has a detection surface facing an outside of the vacuum sealed housing and configured to receive multi-channel measurement optical signals; a photoelectric conversion and synchronous acquisition circuit and a high speed transmission circuit board are placed in the vacuum sealed housing, and the photodetector array is connected to the photoelectric conversion and synchronous acquisition circuit through a signal pin of the photodetector array; the photoelectric conversion and synchronous acquisition circuit is configured to synchronously convert the multi-channel measurement optical signals obtained by the photodetector array into multi-channel digital signals; and the high speed transmission circuit board is configured to perform a serial encoding processing on the converted multi-channel digital signals.

Photoelectric detection device with sealed design and undistorted photoelectric signals, and implementation method thereof

Disclosed herein are cyclic di-nucleotide compounds and derivatives thereof that may be useful as STING agonists, and a pharmaceutical composition comprising the same. Also disclosed herein is the process for synthesis and to uses of such cyclic di-nucleotide compounds in various diseases including cancer, HIV infection and HBV infection.

Cyclic dinucleotides as sting agonists

Disclosed are a control method and apparatus for safety boot of a chip, an electronic device and a storage medium. The method includes: determining, at a preset stage of a chip boot process, first mirror data to be checked at the preset stage and first check code corresponding to the first mirror data, from a decryption result obtained by a hardware security module; determining second check code based on the first mirror data; comparing the second check code with the first check code to obtain a comparison result; determining an integrity check result of the first mirror data based on the comparison result; and executing, based on the integrity check result, a safety boot program corresponding to the first mirror data at the preset stage.

Control method and apparatus for safety boot of chip, electronic device and storage medium

A detection chip, a method for using a dejection chip, and a detection device are provided. The detection chip includes a chip substrate and a first sealing film that are stacked. The chip substrate includes a first surface, and the first sealing film covers the first surface of the chip substrate. The chip substrate further includes a fluid channel on the first surface, and the fluid channel includes a plurality of membrane valve portions. The membrane valve portions are configured to allow a portion of fee first sealing film covering the membrane valve portions to approach and separate, so as to close and open the fluid channel correspondingly.

Detection chip, method for using detection chip, and detection device

Techniques are described with regard to container image configuration in a computing environment. An associated computer-implemented method includes initializing a container image storage engine associated with a logical tree structure having a plurality of container image nodes, where each of the plurality of container image nodes includes a hash layer array and a hash data array. The method includes building at least one new container image node to incorporate into the plurality of container image nodes. The method further includes applying a software patch to a target container image node among the plurality of container image nodes. In an embodiment, the method further includes starting at least one container based upon a respective container image node among the plurality of container image nodes.

Applying a software patch via a container image storage engine

A detection chip, a method for using a detection chip and a detection apparatus are provided the detection chip includes a chip substrate and the chip substrate includes a fluid channel and a plurality of liquid cells. The fluid channel is arranged on a surface if the chip substrate and includes a main path and a plurality of branch paths. The plurality of branch paths are respectively communicated to the plurality of liquid cells, the plurality of branch paths are all communicated to the main path, and communication points between the plurality of branch paths and the main path are different. The plurality of branch paths are configured to allow liquid in the plurality of branch paths to be capable of merging into the main path in a same direction.

Detection chip, method for using detection chip, and detection apparatus

Provided are a semiconductor material based on metal nanowires and a porous nitride, and a preparation method thereof. The semiconductor material includes: a substrate; a buffer layer formed on the substrate; and a composite material layer formed on the buffer layer the composite material layer includes: a transverse porous nitride template layer; and a plurality of metal nanowires filled in pores of the transverse porous nitride template layer.

Semiconductor material based on metal nanowires and porous nitride and preparation method thereof

Solutions preparing container images and data for container workloads prior to start times of workloads predicted through workload trend analysis. Local storage space on the node is managed based on workload trends, optimizing local storage of image files without requiring frequent reloading and/or deletion of image files, avoiding network intensive I/O operations when pulling images to local storage by workload scheduling systems. Systems perform collection of historical data including image and workload properties; analyze historical data for workload trends, including predicted start times, image files needed, number of nodes and types of nodes. Based on predicted future workload start times, nodes are selected from an ordered list of node requirements and workload properties. Selected nodes' local storage is managed using predicted future start times of workloads, to avoid removing image files having sooner start times, while removing (as needed) images files predictively utilized for workloads further into the future.

Storage management and usage optimization using workload trends

A detection chip and a detection system are provided. The detection chip includes a base substrate, a flow channel defining layer, and at least one driving electrode group. The at least one driving electrode group is on the base substrate, and the flow channel defining layer is on a side of the at least one driving electrode group away from the base substrate, the flow channel defining layer includes a flow channel structure, and the flow channel structure is configured to accommodate liquid; and each of the at least one driving electrode group includes a plurality of driving electrodes, and the plurality of driving electrodes are configured to contact the liquid and drive the liquid to move within the flow channel structure.

Detection chip and detection system

Disclosed herein is an imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as a TLR7 agonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as TLR7 agonist.

Imidazo[2,1-f][1,2,4]triazin-4-amine derivatives as TLR7 agonist

Growing community of inventors

Beijing, China

Jing Li