University of California

University of Southern California

Chevron U.s.a. Inc.

Apiqe Holdings, LLC

Cgp Water Systems, LLC

Apiqe Inc

Huang, Jing

Erigican, Erdogan

Jing Huang

Xudong Fu

Karen Lynn Reue

Brett Eugene Lomenick

Laurent Vergnes

Jingyuan Li

Mansoureh Eghbali

Xiang Yin

Suya You

Ulrich Neumann

Amir Anvar

Christopher Lee Fisher

Rui Hao

Nao Jonai

Guan Pang

Michael E Jung

Jay D Keasling

John F Hartwig

Douglas S Clark

Giancarlo Fantappie

Aindrila Mukhopadhyay

Gang Deng

Yanpeng Xing

Erdogan Ergican

Sann Myint Naing

Michael Brandon Casey

Zhennan Liu

Randall M Chin

Min Chai

Mariam Aghajan

Gregory Joseph Baker

Sarah Warburton

Thomas M Vondriska

Yoganathan Thierumaran

Mukul Anil Khairatkar

Simon Diep

Heejun Hwang

Meisheng Jiang

Luciano Nocera

Rongqi Qiu

Erdogan Erigican

Samuel Wheeler French

Ronik Khachatoorian

Brett E Lomenick

Melody Y Pai

Randall Chin

The present invention provides for a genetically modified host cell capable of producing an unnatural compound, such as terpenoid, comprising a P450 enzyme comprising an artificial cofactor, and the host cell is capable of uptaking the artificial cofactor by comprising a heterologous heme transport transmembrane protein, or homologue thereof.

Host cells and methods useful for producing unnatural terpenoids using a novel artificial metalloenzyme

The present disclosure provides compounds of Formula (VIA), Formula (IIIA), Formula (IVA), and Formula (VA). The compounds are prodrugs of alpha-ketoglutarate, alpha-ketobutryrate, alpha-ketoisovalerate, and alpha-ketoisohexanoate, which are useful in treating or preventing age related diseases, disorders, or conditions. 

Prodrugs of alpha-ketoglutarate, alpha-ketobutyrate, alpha-ketoisovalerate, and alpha-ketoisohexanoate, and uses thereof

Disclosed herein are methods of preventing, inhibiting, reducing, or treating ischemia and reperfusion injury to tissues with glutarate compounds such as &#x3b1;-ketoglutarate.

Glutarate compounds for treating ischemia-reperfusion injuries

Disclosed herein are methods for (a) treating, inhibiting, or reducing aging of a subject, (b) treating, inhibiting, or reducing an age-related symptom or an age-related disease in a subject, and/or (c) increasing the lifespan of a subject which comprise administering to the subject one or more ketobutyrate compounds and compositions thereof.

Ketobutyrate compounds and compositions for treating age-related symptoms and diseases

A method of detecting objects in three-dimensional (3D) point clouds and detecting differences between 3D point clouds and the objects therein is disclosed. A method includes receiving a first scene 3D point cloud and a second scene 3D point cloud, wherein the first scene 3D point cloud and the second scene 3D point cloud include first and second target objects, respectively; aligning the first scene 3D point cloud and the second scene 3D point cloud; detecting the first and second target objects from the first scene 3D point cloud and the second scene 3D point cloud, respectively; comparing the detected first target object with the detected second target object; and identifying, based on the comparison, one or more differences between the detected first target object and the detected second target object. Further aspects relate to detecting changes of target objects within scenes of multiple 3D point clouds.

Multi-view 3D object recognition from a point cloud and change detection

An apparatus is disclosed including: a housing including a conduit having an inlet port and an outlet port; an insert at least partially disposed within the conduit and including a tapered portion extending from a narrower end proximal the inlet port to a wider end distal the inlet port; and a facility for adjusting the position of the insert within the conduit. In some embodiments, the apparatus is configured to receive a mixed flow of liquid and gas at the inlet port, direct the mixed flow through the conduit around a portion of the insert disposed within the chamber, and outlet the mixed flow at the outlet port.

Flow compensator

A scene point cloud is processed and a solution to an inverse-function is determined to determine its source objects. A primitive extraction process and a part matching process are used to compute the inverse function solution. The extraction process estimates models and parameters based on evidence of cylinder and planar geometry in the scene. The matching process matches clusters of 3D points to models of parts from a library. A selected part and its associated polygon model is used to represent the point cluster. Iterations of the extraction and matching processes complete a 3D model for a complex scene made up of planes, cylinders, and complex parts from the parts library. Connecting regions between primitives and/or parts are processed to determine their existence and type. Constraints may be used to ensure a connected model and alignment of its components.

Three-dimensional point processing and model generation

In certain embodiments this invention pertains to the discovery that inhibition of the expression and/or activity of eukaryotic initiation factor 4A (eIF4A) inhibits the aging process. Accordingly, in certain embodiments, methods are provided for inhibiting/slowing aging. The methods typically involve administering to a mammal an agent that inhibits the expression and/or activity of eukaryotic initiation factor 4A (eIF4A) in an amount sufficient to inhibit expression or activity of EIF4A, where the agent is not resveratrol.

Use of Pateamine A for the treatment of age-related muscle wasting

An apparatus is disclosed for dispensing water including: a main inlet configured to receive water from a source; a chilled water line, including: an in-line carbonator; a carbonator water inlet valve configured to selectively direct water from the main inlet to the carbonator; a carbonator gas inlet valve configured to selectively direct carbonating gas to the carbonator; and a chilled water line outlet. The apparatus may be integrated in a refrigerator or other major appliance.

Water dispenser system

A system and method of detecting one or more objects in a three-dimensional point cloud scene are provided. The method includes receiving a three-dimensional point cloud scene, the three-dimensional point cloud scene comprising a plurality of points; classifying at least a portion of the plurality of points in the three-dimensional point cloud into two or more categories by applying a classifying-oriented three-dimensional local descriptor and learning-based classifier; extracting from the three-dimensional point cloud scene one or more clusters of points utilizing the two or more categories by applying at least one of segmenting and clustering; and matching the extracted clusters with objects within a library by applying a matching-oriented three-dimensional local descriptor.

System and method of detecting objects in scene point cloud

Drug affinity responsive target stability (DARTS) is a method of drug target ID with several significant advantages over current techniques. In certain embodiments the method involves contacting a sample comprising one or more protein target(s) with a test agent to form a sample/test agent mixture; contacting the mixture with a protease; and identifying a protein or protein fragment that is protected from proteolysis, wherein the protection from proteolysis is an indicator that the protein or protein fragment binds to or interacts with the test agent.

Ligand binding stabilization method for drug target identification

Growing community of inventors

Los Angeles, CA, United States of America

Jing Huang