Basf Se Corporation

Akzo Nobel Chemicals International B.v.

Zhejiang Bossan Pharmaceutical Co. Ltd.

Shanghai Ici Research & Development & Management Co. Ltd.

Jing He

Qing Shan Zhang

Horst Binder

Harald Schaefer

Olaf Klobes

Liang Han

Qiang Yu

Harald Schäfer

Shintaro Gomyo

Woosuk Lee

The present invention provides an anti-tumor use of Anagrelide and derivatives thereof and, more specifically, the present invention provides the use of Anagrelide and derivatives thereof in the preparation of pharmaceuticals or pharmaceutical compositions for the treatment or inhibition of tumors.

Anti-tumor use of anagrelide and derivatives thereof

The present invention relates to a new process for preparing polyisocyanates containing isocyanurate groups and being flocculation-stable in solvents from (cyclo)aliphatic diisocyanates.

Process for preparing polyisocyanates which are flocculation-stable in solvents from (cyclo)aliphatic diisocyanates

Process for the preparation of polysulfide of formula (I) HS&#x2014;(CH)&#x2014;O&#x2014;(CH)&#x2014;O&#x2014;(CH)&#x2014;[S&#x2014;S&#x2014;CH)O&#x2014;(CH)&#x2014;O&#x2014;(CH2)]&#x2014;SH (I) wherein m is an integer in the range 1 to 4, n and p are integers in the range 1-10, and q is an integer in the range 1-60, by oxidizing a bismercaptodiether compound of formula (II) HS&#x2014;(CH)&#x2014;O&#x2014;(CH)&#x2014;O&#x2014;(CH)&#x2014;SH (II) with elemental sulfur in the presence of a base and a protic solvent. This process has a high selectivity towards linear disulfides.

Process for the preparation of a polysulfide

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Shanghai, China

Jing He