Institute of Medical Support Technology, Academy of System Engineering, Academy of Military Science

Tiangong University

Institute of Medical Support Technology of Academy of System Engineering of Academy of Military Science

Jing Guan

Jing Wang

Jian Yang

Feng Tian

Zhihong Li

Jimin Wu

Chunlai Wang

Sheng Ding

Miaolei Jing

Xuexin Chu

Shujie Huang

The present invention relates to an alkyl chitosan-graphene oxide composite sponge and preparation method and application thereof. The alkyl chitosan-graphene oxide composite sponge provided by the present invention includes alkyl chitosan and graphene oxide absorbed on the alkyl chitosan, and the adsorbing capacity of the graphene oxide is 3-28 wt. %. In the present invention, alkyl chitosan is used as a matrix to combine graphene oxide and alkyl chitosan; the obtained composite sponge has excellent hemostatic performance and blood absorption capacity. Results of embodiments indicate that the in-vitro whole blood coagulation time is less than 58 s, the hemostasis time of a rabbit femoral artery hemorrhage model is less than 155 s, the hemorrhage mass is less than 5.4 g, and the hemostatic effect is superior to a pure alkyl chitosan sponge or graphene oxide powder when the composite sponge provided by the present invention is used for hemostasis.

Alkyl chitosan-graphene oxide composite sponge and preparation method and application thereof

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Beijing, China

Jing Guan