Ascentage Pharma (suzhou) Co., Ltd.

Ascentage Pharma Group Corp Limited

Jing Deng

Yifan Zhai

Dajun Yang

Douglas Dong Fang

Lin Zhang

Qiuqiong Tang

Guangfeng Wang

Miaozhen Qiu

Provided herein are pharmaceutical compositions comprising an MDM2 inhibitor and one or more anti-cancer agents for preventing and/or treating diseases, such as cancer. Methods for preventing and/or treating diseases, such as cancer, comprising administering to the patient in need thereof with the pharmaceutical compositions are also provided.

Pharmaceutical composition of MDM2 inhibitor and use thereof for preventing and/or treating disease

The present disclosure provides a pharmaceutical composition comprising a Bcl-2/Bcl-xL inhibitor, a chemotherapeutic agent, and a pharmaceutically acceptable carrier. The present disclosure also provides a method of treating cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a Bcl-2/Bcl-xL inhibitor and a therapeutically effective amount of a chemotherapeutic agent. The present disclosure also provides use of a combination of a Bcl-2/Bcl-xL inhibitor and a chemotherapeutic agent in the manufacture of an anti-tumor medicament. In the present disclosure, a significantly enhanced anti-tumor effect can be achieved by administration of a Bcl-2/Bcl-xL inhibitor in combination with a chemotherapeutic agent.

Combination of BCL-2/BCL-XL inhibitors and chemotherapeutic agent and use thereof

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Suzhou, China

Jing Deng