Shenzhen Neptunus Pharmaceutical Research Institute Co., Ltd.

Jing'an Yang

Jing Wu

Tian Tang

Yanqing Wang

Lin Yu

Hanlin Feng

Feng Jin

Tao Shi

Yanping Chen

Xiarou Liu

Zhiying Huang

Provided in the present invention are a crystal form of a small molecule immune compound, a preparation method therefor and a pharmaceutical composition containing the same; the compound is (3Z,6Z)-3-[((E)-3-(5-tert-butyl)-1H-imidazolyl-4-yl)methylene]-6-((E)-3-(3-fluorophenyl)-2-propenylene)piperazine-2,5-dione; the crystal form thereof has stable morphology, good chemical stability, high temperature resistance, and is used for treating hyperproliferative diseases. The structural formula of the compound is as shown in formula (I). 

Crystal form of small molecule immune compound, preparation method thereof and pharmaceutical composition containing the same

Provided is a composition of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(ethoxy)-6-quinazolinyl]-4-(dimethylamino)-2-butenamide p-toluene sulfonate 1.5 hydrate &#x3b1;-polymorph. The &#x3b1;-polymorph has a stable form, a defined melting point, a good chemical stability, and a good endurance to high temperature and light irradiation, and is suitable for pharmaceutical use.

Crystal form of neptinib di-p-methylbenzenesulfonate, preparation method thereof, and pharmaceutical composition containing same

Growing community of inventors

Guangdong, China

Jing'an Yang