Shanghai Yuansong Biotechnology Co. Ltd.

Jinfa Gu

Xinyuan Liu

Kangjian Zhang

Xianlong Fang

Provided is an oncolytic virus expressing interferon. Specifically provided is an oncolytic adenovirus comprising a fusion protein expressing interferon, said oncolytic virus being capable of effectively suppressing tumors in vitro and in vivo.

Oncolytic virus expressing interferon and application therefor

Provided is an oncolytic virus expressing a PD-1 binding protein, i.e., an oncolytic adenovirus comprising a fusion protein expressing a PD-1 single-chain antibody, wherein the fusion protein has a structure of S-V-L-V-Fc, S is an optional signal peptide sequence, Vis the light chain variable region of the PD-1 single-chain antibody, L is a flexible linker, Vis the heavy chain variable region of the PD-1 single-chain antibody and Fc is an immunoglobulin Fc fragment.

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Shanghai, China

Jinfa Gu