Gilead Pharmasset LLC

Gilead Sciences, Inc.

Pharmasset, Inc.

Jinfa Du

Michael Joseph Sofia

Peiyuan Wang

Dhanapalan Nagarathnam

Tetsuya Kobayashi

Rick Andrew Lee

Byoung-Kwon Chun

Ganapati Reddy Pamulapati

Bruce Ross

Suguna Rachakonda

Jeff A Zablocki

William John Watkins

Hyung-Jung Pyun

Scott E Lazerwith

Michael L Mitchell

Thorsten A Kirschberg

Britton Kenneth Corkey

Robert H Jiang

Jonathan William Medley

Joshua A Kaplan

Samuel E Metobo

Philip Anthony Morganelli

Michael R Mish

Neil H Squires

Hai Yang

David Sperandio

Ruben Martinez

Gregory F Chin

Evangelos Aktoudianakis

Kristyna M Elbel

Sophia L Shevick

Sophie Shevick

Junxing Shi

Wonsuk Chang

Hai-Ren Zhang

Manuel Munoz

Wojciech Stec

Kyoichi A Watanabe

Jeremy Clark

Dhanpalan Nagarathnam

Phillip Furman

Byoung Kwon Chun

Wojciech Kolonia Wola Zaradzynski Stec

This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

Substituted pyrrolizine compounds and uses thereof

Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.

Nucleoside phosphoramidate prodrugs

The present invention provides (i) processes for preparing a 2'-deoxy-2&#x2032;-fluoro-2&#x2032;-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2&#x2032;-deoxy-2&#x2032;-fluoro-2&#x2032;-C-methyl-&#xdf;-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.

Preparation of 2'-fluoro-2&#x2032;-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives

This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R, R, R, R, R, R, R, and Rare described herein.

Benzimidazole derivatives as bromodomain inhibitors

Embodiments of the invention are to compounds, methods, and compositions for use in the treatment of viral infections. More specifically embodiments of the invention are 2',4&#x2032;-substituted nucleoside compounds useful for the treatment of viral infections, such as HIV, HCV, and HBV infections.

2',4&#x2032;-substituted nucleosides as antiviral agents

Disclosed herein are 2'-spiro-nucleosides and derivatives thereof useful for treating a subject infected by hepatitis C virus or dengue virus.

2'-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections

This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R, R, R, R, R, and X are described herein.

Benzimidazolone derivatives as bromodomain inhibitors

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New Hope, PA, United States of America

Jinfa Du