Shenzhen Chipscreen Biosciences, Ltd.

Shenzhen Chipscreen Biosciences Co., Ltd.

Jindi Yu

Zhibin Li

Xianping Lu

Song Shan

Zhiqiang Ning

Jiangfei Zhu

Desi Pan

Xian-Ping Lu

Xianghui Wang

Lijun Xin

Chao Fu

Qianjiao Yang

Xiangheng Liu

The invention discloses a type of fused imidazole compound, preparation method and application thereof. The structure of the compound is shown in general formula I. The definition of each group therein is as described in the specification. These compounds are capable of selectively inhibiting indoleamine 2,3-dioxygenase (IDO). The compounds can act as an IDO inhibitor for treating and/or preventing a disease having a pathological feature with IDO-mediated tryptophan metabolic pathways, for example, cancer, eye disease, autoimmune disease, psychological disorder, depression symptom, anxiety disorder and other diseases.

Fused imidazole compound having indoleamine 2,3-dioxygenase inhibitory activity

An application of a compound having general formula (I) as JAK3 and/or JAK1 kinase and a preparation method for the compound.

Preparation method for aromatic heterocyclic compound used as selective JAK3 and/or JAK1 kinase inhibitor and application of aromatic heterocyclic compound

Isolated compounds of formula I: and stereoisomers, enantiomers, diastereomers, and pharmaceutically acceptable salts thereof are described, as well as processes for production, and methods of use of these compounds and compositions thereof for the treatment of diseases associated with abnormal protein kinase activities and/or abnormal histone deacetylase activities including, for example, inflammatory diseases, autoimmune diseases, cancer, neurological and neurodegenerative diseases, cardiovascular diseases, metabolic disease, allergies and asthma and/or hormone-related diseases.

Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors

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Guangdong, China

Jindi Yu