Shanghai University of Engineering Science

Shanghai University of Medicine & Health Sciences

Shanghai Union Technology Corporation

Jincheng Wang

Yongsheng Zhang

Gang Huang

Sihao Chen

Anyang Sun

Pinhua Rao

Xiuhong Lu

Xuebin Wang

Runkai Wang

Jinjing He

Xianfei Chen

Qingxiao Yu

The present invention relates to an isoindol-sulfilimine compound and its preparation and its use as a sigma-2 receptor inhibitor. Compared with the prior art, the isoindol-sulfilimine compound prepared by the present invention can effectively inhibit the sigma-2 receptor activity by binding to the sigma-2 receptor and deformationally regulating the sigma-2 receptor complex, which will lead to the instability of the binding of adjacent Aβ oligomers to the receptor on the synapse, thus leading to the removal of AB oligomers from the synapse. It can be further used for the preparation of new therapeutic drugs for tumor and neurodegenerative diseases.

Isoindol-sulfilimine compound and use as a sigma-2 receptor inhibitor thereof

A method for preparing a soil conditioner comprises the following steps: swelling alginates in distilled water to obtain alginate gel; adding chitosan to prepare an alginate/chitosan composite material; reacting with N-isopropylacrylamide, and dissolving the obtained reaction product in water to obtain an aqueous phase; dissolving a soil conditioning material in a solvent to obtain an oil phase; mixing the oil phase with the aqueous phase, and performing stirring reaction and centrifugal separation to prepare the product. Compared with the prior art, the present invention implements conditioning and intelligent controlled release of soil by means of molecular structure design and composition control.

Method for preparing soil conditioner

Growing community of inventors

Shanghai, China

Jincheng Wang