Dow Global Technolgoies LLC

Nutrition & Biosciences USA 1, LLC

Jin Zhao

Roland Adden

Matthias Knarr

Neal J Fetner

David L Malotky

Meinolf Brackhagen

Michael D Read

Kevin R Hughes

Kyung W Suh

Johan A Thoen

Michael Leo Tulchinsky

Oliver Petermann

Thomas H Kalantar

Robert L Sammler

Robert L Schmitt

Martin H Tusim

Mladen Ladika

J Keith Harris

Eung Kyu Kim

Karen A Coppens

Michael J Devon

Thomas J Styranec

Pearl L Crossen

Brian Koblinski

Pearl Crossen

An aqueous composition comprising a cellulose ether acetate being at least partially dissolved in an aqueous liquid is produced in a process, wherein an aqueous liquid is mixed with a cellulose ether acetate having a degree of substitution of acetyl groups, DSAc, of from 0.05 to 0.75 and the temperature of the mixture of the cellulose ether acetate and the aqueous liquid is set to less than 10 C to at least partially dissolve the cellulose ether acetate in the aqueous liquid.

Aqueous solution of cellulose ether acetate

A process for producing an aqueous composition comprising a dispersed esterified cellulose ether comprises the steps of grinding, in the presence of an aqueous diluent an esterified cellulose ether comprising (i) groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA, wherein R is a N divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, blending a salt of a fatty acid with the esterified cellulose ether and choosing the amounts of aqueous diluent, esterified cellulose ether and salt of a fatty acid that the produced aqueous composition comprises at least 20 percent of the dispersed esterified cellulose ether and heating the aqueous composition to a temperature of from 37 to 80 C during or after the grinding step.

Process for producing dispersion of esterified cellulose ether

An aqueous composition useful for producing capsules shells comprises a) at least one dispersed esterified cellulose ether comprising (i) groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and b) from 0.05 to 20 percent of at least one salt of a fatty acid, based on the weight of the dispersed esterified cellulose ether, wherein the median particle size, d50, of the dispersed esterified cellulose ether particles is up to 7 micrometers, such median particle size (d50) being the size at which 50 mass percent of the particles have a smaller equivalent diameter and 50 mass percent have a larger equivalent diameter.

Dispersion comprising an esterified cellulose ether

An aqueous composition comprising at least 10 weight percent of a dispersed esterified cellulose ether, based on the total weight of the aqueous composition, wherein the esterified cellulose ether comprises (i) groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOH or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOH, R being a divalent aliphatic or aromatic hydrocarbon group, and at least a part of the groups &#x2014;C(O)&#x2014;R&#x2014;COOH are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid, and wherein d90 of the dispersed esterified cellulose ether particles is up to 10 micrometers, d90 being the diameter where 90 mass percent of the particles have a smaller equivalent diameter and the other 10 mass percent have a larger equivalent diameter, is useful for preparing coating dosage forms including tablets, capsules and others, or for the formation of capsules shells.

Dispersion comprising a partially neutralized esterified cellulose ether

A polymeric capsule shell of high quality is prepared from an aqueous composition which comprises (A) at least one esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOH, R being a divalent aliphatic or aromatic hydrocarbon group, wherein at least a part of the groups &#x2014;C(O)&#x2014;R&#x2014;COOH are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid, and (B) from 0 to 7 weight percent of a non-polymeric plasticizer, based on the weight of the esterified cellulose ether, wherein the weight of said at least one esterified cellulose ether is at least 80 percent of the total polymer weight in the aqueous composition.

Capsule shells comprising an esterified cellulose ether

An injection-molded shell of a dosage form of good quality is producible by a) providing a composition comprising i) from 25 to 90 weight percent of ethylcellulose, ii) from 7.5 to 60 weight percent of a polysaccharide or polysaccharide derivative being different from ethylcellulose, and iii) from 2.5 to 50 weight percent of at least one component being different from polysaccharides and polysaccharide derivatives, based on the total weight of the composition, with the proviso that the composition comprises zero or not more than 10 weight percent of gelatin and zero or not more than 10 weight percent of a polymer comprising homo- or copolymerized acrylic acid, homo- or copolymerized methacrylic acid, a homo- or copolymerized acrylate or a homo- or copolymerized methacrylate, and b) subjecting the composition to shearing and heat to plasticize the composition and injection-molding the plasticized composition into a three-dimensional shell of a dosage form.

Injection-molded dosage form

The present invention relates to the use of polyalkoxylated alcohols of the formula R&#x2014;O-(AO)&#x2014;H, wherein R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl or heterocyclic group having 7 to 25 carbon atoms, (AO) is a polyoxyalkylene moiety of the composition (BO)m(EO)n(DO)r with random or blockwise arrangement of the constituting oxyalkylene units, wherein m, n and r represent the average number of oxybutylene (BO) units, oxyethylene (EO) units and oxyalkylene units derived from at least one epoxide selected from styrene oxide and alkylene oxides having from 5 to 10 carbon atoms (DO) per molecule of the polyalkoxylated alcohol, respectively, m being a number greater than or equal to 1, n being a number greater than or equal to 1 and r being a number in the range from 0 to 50 under the proviso that (m+n+r) is less than or equal to 200 and the ratio n/(m+r) is in the range of 1 to 20, as excipients in pharmaceutical compositions. Said polyalkoxylated alcohols enable very effective solubilization of poorly soluble active pharmaceutical ingredients in aqueous media. Solid or semi-solid pharmaceutical compositions comprising one or more such polyalkoxylated alcohol combined with at least one active pharmaceutical ingredient are further long term stable under typical storage conditions and can be readily provided in various dosage forms such as tablets and filled capsules.

Polyalkoxylated alcohols as excipients for pharmaceutical compositions

Cellulose ethers are described herein which are useful in capsules or in coatings for dosage forms. In these cellulose ethers the ether substituents are methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl, the cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxy groups of anhydroglucose units are substituted with methyl groups such that [s23/s26&#x2212;0.2*MS(hydroxyalkyl)] is 0.35 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.

Cellulose ethers and their use

Low viscosity functional fluids are described which comprises methoxy polyethylene glycol. The fluids are particularly well-suited for use as DOT 4 brake fluids and provide high ERBP, WERBP, low kinematic viscosity and low SBR volume % increase.

Low viscosity functional fluids

The invention includes a process for providing a coupled propylene polymer foam. The invention also includes any composition comprising a product formed by the process of the invention and any article formed from such a composition.

Propylene polymer coupling and foams

The present invention relates to a foam, a process for preparing the foam and an article containing the foam. The foam contains a coupled propylene polymer and has a density in of from 9.6 to 801 kg/m and has either a foamability factor of more than 1.8 to less than 2.8 and an open cell content less than 20 percent, or a foamability factor of at least 2.8 and less than 15 and an open cell content of less than 50 percent. The process includes heating a coupled propylene polymer having a melt flow rate from 0.2 to 20 g/10 min and a melt strength of at least 39 cN to a molten state to produce a molten polymer material and mixing said molten polymer material with a blowing agent under conditions to produce a foamed material having a density in the range of from 9.6 to 801 kg/m .

Growing community of inventors

Midland, MI, United States of America

Jin Zhao