Rstech Co., Ltd.

Rstech Corporation

Jin Won Yun

Ho Seong Lee

Seong Jin Kim

Chang Soo Lee

Geon Joong Kim

Dae-Woon Park

Geon-Joong Kim

Kyung-Hyun Gahm

Ho Cheol Kim

The present invention relates to new chiral salen catalysts and methods for the preparation of chiral compounds from racemic epoxides by using new catalyst. More particularly, the present invention is to provide novel chiral salen catalysts and their uses for producing chiral compounds having high optical purity to be used as raw materials for preparing chiral medicines or food additives in a large scale economically, wherein the chirl salen catalyst having a particular molecules structure can be reused continuously without any activating process of used catalysts and cause no or little racemization after the reaction is completed because it maintains its catalytic activity after the reaction process.

Chiral salen catalyst and methods for the preparation of chiral compounds from racemic epoxides by using new catalyst

The present invention relates to a process for preparing (&minus;)-(18-crown-6)-2,3,11,12-tetracarboxylic acid and its use for (&minus;)-chiral stationary phases for resolution of racemic compounds. More particularly, the present invention relates to the process for preparing (&minus;)-(18-crown-6)-2,3,11,12-tetracarboxylic acid expressed by formula (1) and the use thereof as a stationary phases for resolution of racemic compounds, wherein the use of them provides excellent separation of a desired chiral compound from racemic mixture in employing capillary electrophoresis (CE) or liquid chromatography to elute the desired one first by controlling a flowing order of enantioners, thus allowing to be consistently separated in an economical due to much less requirement of eluent, quantitative and high purity manner.

Process for preparing (-)-(18-crown-6)-2,3,11,12-tetracarboxylic acid, and (-)-chiral stationary phases for resolution of racemic compounds using the same

The present invention relates to chiral salen catalysts and a process for preparing chiral compounds from racemic epoxides by using them. More particularly, the present invention is to provide chiral salen catalysts and its use for producing chiral compounds such as chiral epoxides and chiral 1,2-diols economically in high yield and high optical purity by performing stereoselective hydrolysis of racemic epoxides, wherein the chiral salen catalyst comprises a cationic cobalt as a center metal of chiral salen ligand and counterions having weak nucleophilic property to resolve disadvantages associated with conventional chiral salen catalysts, and can be used continuously without any activating process of used catalysts because it does not loose a catalytic activity during the reaction process.

Process for preparing chiral compounds from recemic epoxides by using chiral salen catalysts

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Choongcheongbook-do, South Korea

Jin Won Yun