Polytherics Limited

Jin-Won Choi

Stephen James Brocchini

Antony Robert Godwin

Sunil Shaunak

Elisa Pedone

Novel biologically active compounds of the general formula (I) in which one of X and X' represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X&#x2032; represents a polymer, X-Q-W- together may represent an electron withdrawing group; and in addition, if X represents a polymer, X&#x2032; and electron withdrawing group W together with the interjacent atoms may form a ring; each of Zand Zindependently represents a group derived from a biological molecule, each of which is linked to A and B via a nucleophilic moiety; or Zand Ztogether represent a single group derived from a biological molecule which is linked to A and B via two nucleophilic moieties; A is a Calkylene or alkenylene chain; and B is a bond or a Calkylene or alkenylene chain; are formed by conjugating a suitable polymer to a suitable biologically active molecule via nucleophilic groups in said molecule, preferably via a disulphide bridge. 

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Leytonstone, United Kingdom

Jin-Won Choi