National Taiwan University

Academia Sinica

National Science Council

Jin-Town Wang

Tzu-Lung Lin

Chung-Yi Wu

Shih-Hsiung Wu

Jyh-Chin Yang

Yi-Jiun Pan

Pei-Fang Hsieh

Feng-Chiao Tsai

Yoav Keynan

Han-Chi Fang

Chih-Shen Chang

Jaw-Tow Lin

Hui-Ching Yang

Li-Tzong Chen

Kai-Chih Chang

The disclosure provides various immunogens comprising a repeat unit of saccharide ofCPS, which has a formula selected from the group consisting of Formulae (I) to (VI) as described herein. Also provided are vaccines including one or more immunogens selected from Formula (I) to (VI) and methods of eliciting an immune response against aand preventing infection ofby using an immunogen of the invention.

capsule polysaccharide vaccines

The present invention relates to a method of identifying a serotype of, in particular to a method using specific polymerase chain reaction (PCR) primer sets designed according to a fragment of a capsular polysaccharide synthesis (cps) region to identify a K57 or a NTUH-N1 serotype and its application. NTUH-N1 is a novel serotype which differs from the previously reported 77 serotypes. This PCR-based cps genotyping method not only solves the problems of insufficient specificity and sensitivity caused by conventional immune method, but can be applied in clinical diagnosis with the advantages of rapidity and low cost. In addition, the rate of unidentifiable strains can also be reduced by this method.

[object Object]

Disclosed is a novel type II restriction endonuclease. Such enzyme recognizes a particular non-palindromic sequence of 5 oligonucleotides and cleaves DNA downstream of the DNA recognition sequence of nucleotides at the fourth base in the upper strand and the fifth base in the lower strand, and forms a one-base protruding end in the 5'-end after cleavage. The recognition and cleavage site of HpyC1I is identical to the known restriction endonuclease BccI respectively, but the nucleotide sequence and the amino acid sequence are different from any other know restriction enzymes.

Purified HpyC1I and its use as a restriction endonuclease

The present invention relates to a gene, fldA, a putative flavodoxin gene and whose expression is associated with mucosa-associated lymphoid tissue lymphoma of the stomach (MALToma). A G insertion at position 481 of the fldA gene was more frequently observed in strains associated with MALToma than other strains. Therefore, the present invention provides a new method to identify patient with higher risk of developing gastric MALToma.

FldA gene and methods for detecting predisposition to mucosa-associated lymphoid tissue lymphoma of the stomach

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Taipei, Taiwan

Jin-Town Wang