Chinese Academy of Sciences

Topharman Shanghai Co., Ltd.

Boehringer Ingelheim Pharma Gmbh & Co Kg

Suzhou Vigonvita Life Sciences Co., Ltd.

Topharman Shandong Co., Ltd.

Jin Suo

Jingshan Shen

Xiangrui Jiang

Hualiang Jiang

Zhen Wang

Guanghui Tian

Jianfeng Li

Zheng Liu

Yu Ying Wang

Yang He

Yi Jing Zhu

Rolf Dach

Rongxia Zhang

Xiaojun Yang

Weiming Chen

Yongjian Liu

Weiliang Zhu

Feipu Yang

Xianguo Zhao

Zhu Xie

Yi Zhu

Yu Wang

The present disclosure relates to a maleate salt of a benzothiophene compound, a crystalline form thereof, and a use thereof. Specifically, the present disclosure relates to a compound represented by formula (I-A), a crystalline form A thereof, a preparation method of a pharmaceutical composition including the same, and a use of the pharmaceutical composition in the preparation of drugs for preventing or treating diseases of the central nervous system. The compound represented by formula (I-A) and the crystalline form A thereof in the present disclosure have excellent physical and chemical properties, high oral bioavailability, excellent drugability, and are well-suited for pharmaceutical preparation, application, and preservation. 

Maleate salt of benzothiophene compound, crystalline form thereof, and use thereof

The present invention relates to new salts of pyrazolopyrimidinone represented by formula (I), and pharmaceutically acceptable polymorph, solvate, hydrate, dehydrate, co-crystallization, anhydrous, or amorphous form thereof, the pharmaceutical compositions, and a pharmaceutical unit dosage form containing the same, wherein x represents organic or inorganic acids, preferable maleic acid, succinic acid, methanesulfonic acid, hydrochloric acid, etc. The invention further relates to co-crystals or complexes of compounds of pyrazolopyrimidinone and pharmaceutical compositions containing the same. The present invention also relates to a process for the preparation, use thereof and pharmaceutical preparation containing the salts or crystalline forms. 

Salt and polymorph of pyrazolopyrimidinone compound, and pharmaceutical composition containing the same, preparation method and use thereof

Subject of the present invention is a new improved process for the preparation of nitroorotic acid via nitration of orotic acid.

Process for the preparation of nitroorotic acid

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Shanghai, China

Jin Suo