Daebong Ls Co., Ltd.

Daebong Ls, Ltd

Other

Ucl Co., Ltd.

Jin Oh Park

Ji Won Lee

Hyun Ji

Eun Ju Park

Jae Young Lee

Ji Eun Lee

Hye Ja Lee

Bo Kyung Kwon

Chang Kuk Kim

Eun Mi Kim

Seong Hyeon Jeon

Ji Young Moon

Jeong Mi Kim

Byoung Kwon Park

Soon Myoung Jung

Min Jeong Kim

Mi So Moon

The present invention relates to a co-crystalline form of efinaconazole and a pharmaceutically acceptable coformer forming a co-crystalline phase. The present invention also relates to a method for preparing the co-crystalline form. The co-crystallization product of efinaconazole according to the present invention meets all requirements for use as an active ingredient of a pharmaceutical composition and is highly stable to heat and other one or more other ingredients of the composition. Therefore, the co-crystallization product of efinaconazole is suitable for use in the preparation of pharmaceuticals. In addition, the method of the present invention enables the preparation of the co-crystallization product of efinaconazole in a simple and easy manner on a commercial scale.

Co-crystalline form of efinaconazole and method for preparing the same

The present disclosure relates to a method for extracting caffeic acid and rosmarinic acid fromL., and more particularly, to a method for extracting caffeic acid and rosmarinic acid fromL., the method comprising the steps of: (S1) preparing an extraction apparatus including an extractor for passing a solution contained in a main body unit through a filtration membrane to obtain a filtered solution, and dropping the filtered solution to the lower outside through a dropping unit connected to a lower portion of the main body unit, and a receiver located in the lower part of the extractor to collect the filtered solution that is dropped from the dropping unit; (S2) putting driedL. into the main body unit, and adding a solvent to the main body unit to immerse the driedL. at room temperature; and (S3) dropping a solution in which the driedL. has been immersed from the dropping unit to the receiver.

Method of extracting caffeic acid and rosemarinic acid from rosemary

A solid dispersion of amorphous efinaconazole and a method for preparing the same are proposed. The solid dispersion includes an amorphous form of efinaconazole and at least one stabilization carrier selected from hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), ethyl cellulose (EC), hydroxypropyl methylcellulose acetate succinate (HPMC-AS), polyvinylpyrrolidone (PVP), polyacrylic acid (PAA), saccharin, and malonic acid. The solid dispersion undergoes minimal thermodynamic deformation when exposed to ambient temperature and humidity, achieving improved stability, while maintaining the inherent improved stability and bioavailability of amorphous efinaconazole.

Amorphous efinaconazole solid dispersion

The present invention relates to a novel method for preparing efinaconazole using an ionic liquid as a medium. The method includes subjecting 1-[[(2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole to a coupling reaction with 4-methylenepiperidine or an organic chemically acceptable salt thereof in the presence of a base and an ionic liquid compound. The base makes the 4-methylenepiperidine or organic chemically acceptable salt thereof anionic. The use of the ionic liquid in the method of the present invention prevents the formation of related substances, shortens the reaction time, and enables easy preparation of the final compound efinaconazole in high purity and yield on a large scale, compared to the use of organic solvents in conventional methods.

Method for preparing efinaconazole using ionic liquid as medium

Provided are a novel pseudoceramide compound and uses thereof. The pseudoceramide has antioxidant, anti-inflammatory, skin whitening, and moisturizing effects. In addition, the pseudoceramide can be synthesized in a simple and economically advantageous manner and is free from problems associated with the preparation of cosmetic formulations resulting from low hydrophilicity, thus being suitable for use in cosmetic applications.

Pseudoceramide compound and use thereof

The present invention relates to a novel phenolic acid derivative compound with whitening and antioxidant activities and use thereof. The phenolic acid derivative compound is a compound represented by Formula 1, which is described in the specification, an isomer thereof or a salt thereof. The compound of the present invention has skin whitening activity to inhibit tyrosinase, thus being suitable for use in a pharmaceutical composition or cosmetic product for skin whitening. In addition, the compound of the present invention is suitable for the prevention or treatment of oxidation-derived skin abnormality or disease such as skin aging due to its antioxidant activity.

Phenolic acid derivative compound and use thereof

The present disclosure relates to an apparatus for curing spinal stenosis which is an abnormal narrowing of the spinal canal between spinous processes, more particularly, to an apparatus of fixing spinous processes which can prevent the narrowing or widening of the spinal canal between spinous processes along the motion of the spine so as to enhance spinal stabilization. The apparatus of fixing the spinous processes includes a spacer having at least predetermined portion inserted between spinous processes of two neighboring vertebrae to support the spinous processes so as to prevent narrowing of the spinous processes which is generated by spinal bending; and a clip provided to cover an outer surface of the spinous processes of the two neighboring vertebrae to prevent widening of a distance between the spinous processes generated by the spinal bending.

Apparatus of fixing spinous processes

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Seoul, South Korea

Jin Oh Park