Cansino Biologics Inc.

Tongye Technologies Development Co., Ltd

Jin Ma

Tao Zhu

Xuefeng Yu

Zhongqi Shao

Junqiang Li

Lei Duan

Helen Huihua Mao

Ying Zhang

Weiwei Chen

Haiyan Cui

Chunlin Xin

Huihua Mao

Hua Yin

A multifunctional central suction system capable of remote monitoring includes a flow measurement device and a controller, wherein a negative pressure port of the flow measurement device is connected to a negative pressure air nozzle of the controller via a gas pipe; the flow measurement device includes a measurement mechanism and a liquid bottle; the negative pressure port is arranged on the liquid bottle; a first BLUETOOTH® communication module is provided on the measurement mechanism; a communication module is provided in the controller; the communication module includes a second BLUETOOTH® communication module and a Wi-Fi® communication module; and the first BLUETOOTH® communication module on the measurement mechanism is in communication connection with the second BLUETOOTH® communication module in the controller.

Multifunctional central suction system capable of remote monitoring

Provided are a cell strain HEK293.CS for reducing the production of a replication competent adenovirus, and a construction method and the use thereof. HEK293.CS is a safe adenovirus-producing cell line constructed by knocking out a gene fragment homologous to the Ad5 adenovirus E1 gene in HEK293 and providing a template plasmid to replace said gene fragment with a non-homologous sequence that stabilizes the expression of the E1 gene. Compared with the unmodified HEK293 cell strain, HEK293.CS shows no decrease in growth ability and virus production ability, but does not produce a detectable RCA. HEK293.CS can be used for the mass culture of a recombinant human type 5 adenovirus, and reducing the probability of RCA production in the manufacture process of drugs such as vaccines and antibodies.

Cell strain for reducing production of replication competent adenovirus, and construction method and use thereof

Growing community of inventors

Tianjin, China

Jin Ma