Corning Incorporated

Jin Liu

Theresa Chang

Joydeep Lahiri

Odessa Natalie Petzold

Yulong Hong

Ruchirej Yongsunthon

Ronald Allen Faris

Olivia Grace Weeks

Cell culture compositions containing LFM-A13 or a structurally related compound can enhance global hepatic function. For example, LFM-A13 is shown to enhance levels of a broad variety of drug metabolism enzymes, including CYP enzymes, and other hepatic enzymes. LFM-A13 is also shown to promote differentiation of stem cells into hepatocytes. LFM-A13 and structurally related compounds can be used in cell culture to enhance global drug metabolism of liver cells for enhanced in vitro study the effects of drug metabolism on other candidate drug compounds.

Cell culture medium for enhanced hepatocyte function

A cell culture system including: a substrate, a substrate coating, one or more live cells, and an overlay source. The substrate coating and overlay can be laminin, and laminin&#x2022;entactin complex, respectively. Alternatively, the substrate coating and overlay can be laminin&#x2022;entactin complex, and laminin, respectively. The cell culture system can further include liquid media and a protective cover. A method for making and using the system in cell culture articles and culture methods, as defined herein, is also disclosed.

Laminin-entactin complex and cell culture article and methods thereof

Growing community of inventors

Painted Post, NY, United States of America

Jin Liu