University of California

Syntex (u.s.a.) Inc.

University of Georgia Research Foundation, Inc.

Jin Kyu Lee

Steven D Rosen

Kelley Wilson Moremen

Stefan Hemmerich

J Michael Pierce

Novel glycosylsulfotransferases (GST-4&#x3b1;, GST-4&#x3b2;, and GST-6) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-4&#x3b1;, GST-4&#x3b2;, and GST-6.

Glycosyl sulfotransferases GST-4&#x3b1;, GST-4&#x3b2;, and GST-6

The present disclosure provides a novel family of C-type lectins from vertebrates. As specifically exemplified, this family of lectins includes a melibiose-specific lectin (XL35) from oocytes, and two human lectins, HL-3 and HL-13, specifically expressed in endothelial cells such as blood vessels, stomach, small intestine, heart and tissue and in small intestine, respectively. Amino acid sequences of the lectin proteins are provided herein, together with the nucleotide sequences encoding these proteins.

Lectins and coding sequences

The present disclosure provides a novel family of C-type lectins from vertebrates. As specifically exemplified, this family of lectins includes a melibiose-specific lectin (XL35) from Xenopus laevis oocytes, and two human lectins, HL-3 and HL-13, specifically expressed in endothelial cells such as blood vessels, stomach, small intestine, heart and tissue and in small intestine, respectively. Amino acid sequences of the lectin proteins are provided herein, together with the nucleotide sequences encoding these proteins.

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Alameda, CA, United States of America

Jin Kyu Lee