Yonsei University

Gwangju Institute of Science and Technology

Kyungpook National University Industry-academic Cooperation Foundation

Korea Advanced Institute of Science and Technology

Seoul National University

Curacle Co., Ltd.

Yooho Development & Construction Co. Ltd.

Jin Hee Ahn

Haushabhau Shivaji Pagire

Min Jae Lee

Hee Kyung Jin

Jae Sung Bae

Hye Jin Lim

Myung Shik Lee

In-Kyu Lee

Jae-Han Jeon

Seung Soo Han

Myung-Hwa Kim

Hail Kim

Jung-In Pyo

Eun Jung Bae

Myung-Shik Lee

Ko Eun Shong

Hyejin Lim

Young Eui Jeon

Suvarna Haus-habhau Pagire

H S Pagire

Jaemyoung Suh

Ajin Lim

Sang Hyo Kim

Kyu Tae Choi

Kwang-eun Kim

Haiying Zhang

Jung Ho Yoo

Chang Keon Cho

Kun-Young Park

Suvarna Haus-Habhau Pagire

The present invention relates to a novel tryptophan hydroxylase inhibitor and a pharmaceutical composition including same, wherein the novel tryptophan hydroxylase inhibitor has an excellent inhibitory effect on TPH1, and thus can be usefully used for the prevention or treatment of disorders, such as metabolic disorders, cancer, digestive or cardiovascular system disorders, related to TPH1 activity. In particular, the novel tryptophan hydroxylase inhibitor has an excellent treatment effect on inflammatory bowel disorders, and thus can be usefully used for the treatment of inflammatory bowel disorder.

Tryptophan hydroxylase inhibitor and pharmaceutical composition including same

The present invention relates to a novel phenylsulfonyl oxazole derivative and a use thereof and specifically, to a compound represented by Chemical Formula 1 in the present specification or a pharmaceutically acceptable salt thereof, and to a use thereof for prevention, treatment, or improvement of neurodegenerative disease.

Phenylsulfonyl oxazole derivative and use thereof

Provided are a compound of chemical formula 1 or 2 and a use thereof. The compound can be advantageously used in the prevention or treatment of metabolic diseases including type 2 diabetes, insulin resistance, or obesity, on the basis of a mechanism of autophagy activation through the promotion of lysosome production.

Autophagy enhancer and use thereof

A steel structure including pre-stressing brackets for improving load-carrying capacity and serviceability comprises: a steel girder; a plurality of connecting brackets connected to the bottom surface of the steel girder spaced and apart from one; and a cover plate connected to the bottom surfaces of the connecting brackets. Since the cover plate is installed regardless of the connecting portion of the steel girder, pre-stressing section can be consecutively formed therefore pre-stress effect is improved. Moreover, since the connecting brackets space the cover plate a constant distance from the steel girder, the moment of inertia is increased so the span of a bridge might be increased.

Steel structure including pre-stressing brackets for improving load-carrying capacity and serviceability

Growing community of inventors

Gwangju, South Korea

Jin Hee Ahn