United Kingdom Research and Innovation

N.v. Nutricia

Imperial Innovations Limited

Jimmy David Bell

Andrew David Miller

Günther Boehm

Eline Marleen Van Der Beek

Christopher Beermann

Gary Frost

Tammy Louise Kalber

Maya Thanou

Meliz Sahuri Arisoylu

Neena Modi

Elizabeth Louise Thomas

Nazila Kamaly

Gavin David Kenny

Leigh Brody

The present invention provides novel liposomes comprising Gd.DOTA.DSA (gadolinium (III) 2-{4,7-bis-carboxymethyl-10-[(N,N-distearylamidomethyl-N'-amido-methyl]-1,4,7,10- =tetra-azacyclododec-1-yl}-acetic acid), characterised in that the liposome further comprises a neutral, fully saturated phospholipid component (e.g. DSPC (1,2-distearoyl-sn-glycero-3-phospocholine]), which are of particular use in the preparation of magnetic resonance contrast agents for enhancing a magnetic resonance image of tumours in a mammal.

Liposome nanoparticles for tumor magnetic resonance imaging

The present invention concerns nanoparticle formulations suitable for the delivery of one or more therapeutic agents, the formulations comprising: a cationic cholesterol derivative; a neutral phospholipid; cholesterol or a neutral cholesterol derivative; and a saturated fatty acid, PEGylated neutral derivative of phosphatidylethanolamine or phosphatidylcholine.

Nanoparticle formulation

The present invention relates to human milk fortifiers comprising high protein content and long chain poly-unsaturated fatty acids. Use of such human milk fortifier improves the body adipose tissue distribution by increasing the subcutaneous adipose tissue mass, while at the same time not increasing visceral adipose tissue.

Human milk fortifier with high protein and long chain poly unsaturated fatty acids for improving body adipose tissue distribution

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London, United Kingdom

Jimmy David Bell