Schering Corporation

Jimmy C Tan

Paul J Zavodny

Barbara Dalie

Daniel Lundell

Charles A Lunn

Xuedong Fan

Kevin W Moore

Chuan-Chu Chou

Di-Hwei Hsu

Ying Liu

Alice Suk-Yue Ho

J Fernando Bazan

Bazan Fernando J

The present invention provides isolated human and bovine TNF-&#x3b1; convertases, nucleic acids and; recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-&#x3b1;. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-&#x3b1; convertases, and for identifying nucleic acids encoding such convertases.

Nucleic acids encoding human TNF-&#x3b1; convertase

The present invention provides isolated human and bovine TNF-&#x3b1; convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-&#x3b1;. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-&#x3b1; convertases, and for identifying nucleic acids encoding such convertases.

Mammalian TNF-&#x3b1; convertases

The present invention provides isolated human and bovine TNF-&agr; convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-&agr;. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-&agr; convertases, and for identifying nucleic acids encoding such convertases.

Mammalian TNF- &agr; convertase

Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.

Mammalian receptors for interleukin-10

Mammalian TNF-&agr; convertases

Mammalian receptors for interleukin-10 (IL-10)

Antibodies which specifically bind mammalian receptors for

The present invention provides isolated human and bovine TNF-.alpha. convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-.alpha.. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-.alpha. convertases, and for identifying nucleic acids encoding such convertases.

Mammalian TNF-.alpha. convertases

Growing community of inventors

Edison, NJ, United States of America

Jimmy C Tan