University of Texas System

The University of Arizona

Health Research, Inc.

Jimin Xu

Jia Zhou

Pei-Yong Shi

Xuping Xie

Zhong Li

Hongmin Li

Qing-Yu Zhang

A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2′,5(3H)-dione analogues, the use thereof and the preparation thereof.

Substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2',5(3H)-dione analogues

The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present disclosure further relates to methods of inhibiting viral replication including contacting one or more cells that have been infected with a virus with an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the virus comprises a flavivirus. Also disclosed is a method of treating and/or preventing a flavivirus infection and/or a condition resulting from a flavivirus infection including administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof under conditions effective to treat and/or prevent a flavivirus infection and/or a condition resulting from a flavivirus infection.

Compounds and methods for inhibiting viral replication and methods of treating and preventing flaviviral infections

A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2&#x2032;,5(3H)-dione analogues, the use thereof and the preparation thereof.

Substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2&#x2032;,5(3H)-dione analogues

Growing community of inventors

Galveston, TX, United States of America

Jimin Xu