Valeant Pharmaceuticals International

Hoffmann-la Roche Inc.

Valeant Research and Development

Jim Zhen Wu

Huanming Chen

Jean-Michel Andre Vernier

Li Chen

Lichun Feng

Yongfu Liu

Mengwei Huang

Jianlan Song

Tao Guo

Hongying Yun

Lisha Wang

Martha Alicia De La Rosa

Chungen Liang

Mingwei Zhou

Xiufang Zheng

Lu Gao

Song Feng

Guolong Wu

Xihan Wu

Jason Christopher Wong

Gary Lee Larson

Ian Wayne Cheney

Clayton Harris

Haoyun An

Frank Rong

Suetying Chow

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein Rto R, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.

Compounds for the treatment and prophylaxis of respiratory syncytial virus disease

This invention provides a compound of formula A The compound provided herein can affect the opening of, or otherwise modulate, voltage-gated potassium channels. The compound provided herein is useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.

N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators

Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein Rto Rhave the significance given in claim, can be used as a medicament.

3,3-dimethyl tetrahydroquinoline derivatives

The present invention relates to benzyloxyanilide derivatives having the following structural formula: The compounds of the present invention are useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.

Benzyloxy anilide derivatives useful as potassium channel modulators

This invention provides a compound of formula IA where X&#x2550;O or S; Y is O or S; q=1 or 0; and other substituents are defined herein. Such compounds can affect the opening of, or otherwise modulate, voltage-gated potassium channels. They are potentially useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.

Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators

This invention provides compounds of Formula I which are inhibitors of Chk2 and are useful as a radiation protection agents in anticancer radiotherapy. A method of modulating Chk2 in vitro includes treating a substrate with Chk2 in the presence of compounds of formula I. A method of making a compound of formula I includes: a) forming a biaryl amine having an amino (NH) group; b) converting the amino group to an isothiocyanate group; c) adding a cyanoacetamide to the isothiocyanate group to form a thioamide adduct; d) cyclizing the thioamide adduct to form an isothiazole having a cyano group; and e) adding an amine to the cyano group to form a carboxamidine group.

3-hydroxyisothiazole-4-carboxamidine derivatives as CHK2 inhibitors

This invention is directed to compounds of formula I, where G is &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;C(g)(g)-, or &#x2014;NH&#x2014;, and n=1, 2, or 3. Such compounds modulate potassium channels. The compounds are useful for the treatment and prevention of diseases and disorders which are affected by modulation of potassium ion channels. One such condition is seizure disorders.

1,4 diamino bicyclic retigabine analogues as potassium channel modulators

The invention provides substituted quinoxalines having the general formulas where R, R, R, and Rare, inter alia, alkyl, aryl, or heteroaryl groups; Z is NH or O; and X is, inter alia, COOH or CONH. The compounds of the invention have antiviral and immunomodulatory activity and are useful for treating infectious diseases, particularly viral infections.

Quinoxaline derivatives having antiviral activity

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Shanghai, China

Jim Zhen Wu