University of California

Jim Kiriakis

Scott Thomas

Pamela Munster

Hani Sbitany

Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to a hydrophobic active agent, and a silicone tubing having a wall permeable to the active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein the two ends of the silicone tubing extend from the first surface, and wherein a path outlined by a second length of the tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver a hydrophobic active agent to a target tissue, and kits that find use in performing the present method.

Implants for localized drug delivery and methods of use thereof

Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to the hydrophobic active agent, and a silicone tubing having a wall permeable to the hydrophobic active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein two ends of the silicone tubing extend from the first surface, and wherein a path outlined by a second length of the silicone tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver the hydrophobic active agent to the target tissue, and kits that find use in performing the present method.

Growing community of inventors

Corte Madera, CA, United States of America

Jim Kiriakis