Edwards Lifesciences Corporation

Covidien LP

Jim Davidson

Darin P Dobler

Gregory A Wright

Bin Tian

Jeffery Dove

Stephen A Griffin

Masoud Molaei

Michael Losordo

Ashok Nageswaran

Jeff Dove

Darin Dobler

A method of treating a biological tissue that enables dry storage of said tissue is disclosed. In one embodiment, the method comprises contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C-Calcohol and removing a portion of the treatment solution from the solution-treated biological tissue. Also disclosed is biological tissue prepared using the above process and prosthetic devices made with such tissue.

Biological tissue for surgical implantation

An aneurysm therapy system, can include a catheter and an occlusive device. The catheter can have a proximal end, a distal end, and a lumen extending between the proximal and distal ends. The proximal end can include a self-expanding distal section, and the distal section can comprise a coil portion. The occlusive device can be disposed within the lumen and configured to reside in the aneurysm to restrict fluid flow within the aneurysm.

Occlusive devices and methods of use

A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification is disclosed. The method includes preconditioning, pre-stressing, or pre-damaging fixed bioprosthetic tissue in a manner that mimics the damage associated with post-implant use, while, and/or subsequently applying a calcification mitigant such as a capping agent or a linking agent to the damaged tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the damage process (service stress) and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. The linking agent will act as an elastic reinforcement or shock-absorbing spring element in the tissue structure at the site of damage from the pre-stressing. In one method, tissue leaflets in assembled bioprosthetic heart valves are preconditioned by simulating actual flow conditions for a predetermined number of cycles, during or after which the valve is exposed to the capping agent.

Methods for pre-stressing and capping bioprosthetic tissue

A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.

Capping bioprosthetic tissue to reduce calcification

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San Juan Capistrano, CA, United States of America

Jim Davidson