Pfizer Corporation

Elan Pharmaceuticals, Inc.

Jim D Durbin

Timothy Earl Benson

D Bryan Prince

Alfredo Giuseppe Tomasselli

Thomas L Emmons

Donald Bryan Prince

An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three dimensional x-ray crystal structure has been solved to 3.2 &#x212b; resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of human beta secretase activity.

Method for crystallizing human beta secretase in complex with an inhibitor

Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease

The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of human BACE activity.

Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof

The x-ray crystal structure of BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of BACE activity.

Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease

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Portage, MI, United States of America

Jim D Durbin