Dart Neuroscience, LLC

Jillian Basinger Thompson

Brett C Bookser

Andrew Richard Hudson

Lino J Valdez

Benjamin Pratt

Joe Anh Tran

Marco Peters

Pablo Garcia-Reynaga

Scott Burley

Aaron Thompson

Substituted cyclohexyl chemical entities of Formula (I):

Substituted cyclohexyl compounds as NOP inhibitors

Substituted cyclohexyl chemical entities of Formula (I): wherein R, G, and Rhave any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders. 

Substituted cyclohexyl compounds as NOP inhibiiors

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San Diego, CA, United States of America

Jillian Basinger Thompson