Chiron Corporation

Novartis Vaccines & Diagnostics, Gmbh

Jill Winter

Christoph Reinhard

Anne B Jefferson

Deborah Lee Zimmerman

Rhonda Hansen

Shuling Fang

Douglas R Den-Otter

The invention provides, inter alia, models of bone metastasis, methods for identifying agents that modulate skeletal related events and metastasis, methods for modulating skeletal related events and metastases, and methods for detecting skeletal related events and metastases. The methods and models generally comprise co-culturing cancer cells and host cells and comparing biological markers from such co-cultured cells to control cells.

Methods of modulating metastasis and skeletal related events resulting from metastases

Inhibitors of laminin5beta3 are provided that reduce the expression or biological activities of laminin5beta3 or the expression of laminin5beta3 mRNA in a mammalian cell. Laminin5beta3 inhibitors include antisense molecules, ribozymes, antibodies and antibody fragments, proteins and polypeptides as well as small molecules. Laminin5beta3 inhibitors find use in compositions and methods for decreasing laminin5beta3 gene expression as well as methods for inhibiting the proliferation of mammalian cells, including tumor cells of epithelial origin, and methods for treating neoplastic diseases.

Compositions and methods for treating neoplastic disease using inhibitors of laminin5beta3

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Richmond, CA, United States of America

Jill Winter