Janssen Pharmaceutica Nv

Ortho-mcneil Pharmaceutical Corp.

Johnson & Johnson Pharmaceutical Research & Development, LLC

Janssen Pharmaceuticals, Inc.

Jill A Jablonowski

Chandravadan R Shah

Wei Xiao

Wenying Chai

Vi T Tran

James Patrick Edwards

Richard Apodaca

Kiev S Ly

Cheryl A Grice

Ronald L Wolin

Nicholas I Carruthers

Brock T Shireman

Devin M Swanson

Curt A Dvorak

Neelakandha S Mani

Timothy W Lovenberg

Xiaohu Deng

Chennagiri R Pandit

Victoria Wong

Barbara A Pio

Dale A Rudolph

Mark Seierstad

Jennifer Diane Venable

Scott L Dax

William V Murray

Mark Andrew Youngman

Jianmei Wei

John M Keith

Haripada Khatuya

Emily M Stocking

Lars Karlsson

Xiaobing Li

Robin L Thurmond

Annette K Kwok

Siquan Sun

Pascal Bonaventure

Leslie A Gomez

Michael Bogenstaetter

Jennifer D Kreisberg

Siguan Sun

Richard L Apodaca

Barbara Pio

Certain biphenyic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

Serotonin receptor modulators

Certain biphenyl compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

Modulators of serotonin receptors

The biphenyic compounds of formula (I) are serotonin modulators useful in the treatment of serotonin-mediated diseases. 

Modulators of serotonin receptor

The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility. The compounds of the present invention are of the formula where Ring T is a heterocycloalkyl ring selected from the group consisting of: 

Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor

Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine Hreceptor, including allergic rhinitis.

Heterocyclic compounds

Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.

Phenylalkynes

Substituted piperazinyl and diazepanyl benzamides and benzthioamides of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.

Piperazinyl and diazapanyl benzamides and benzthioamides

The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.

Non-peptidic NPY Y2 receptor inhibitors

Substituted phenylalkynes of formula (I) compositions containing them and their methods of use to treat histamine related disorders are described, wherein R, R, R, R, Rand n are as defined.

The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I): 

2-oxy, 2-amino, and 2-thio-imidazole compounds

Disclosed are substituted phenylalkynes of formula (I),wherein R, R, R, R, Rand n are as defined, compositions containing them, and methods of making and using them to treat histamine-mediated conditions.

Heterocyclic compounds and methods of making them and using them.

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San Diego, CA, United States of America

Jill A Jablonowski