The Johns Hopkins University

Mirna Therapeutics, Inc.

Asuragen, Inc.

Jikui Shen

Peter Anthony Campochiaro

David Allen Brown

Kevin Kelnar

Jeffrey Shelton

Jordan J Green

Jayoung Kim

David Brown

The presently disclosed subject matter provides compositions and methods for administering a nanoparticle or microparticle and a therapeutic agent to the suprachoroidal space in the eye.

Nonviral gene transfer to the suprachoroidal space

The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed.

Compositions and methods related to miRNA modulation of neovascularization or angiogenesis

Growing community of inventors

Dundlak, MD, United States of America

Jikui Shen