Korea Institute of Science and Technology

Jihye Seong

Youngjae Kim

Ae Nim Pae

Ji Yeon Song

Yun Kyung Kim

Yong Seo Cho

Hyunah Choo

Hyojin Kim

Ghil Soo Nam

Jae Wook Lee

Sang Min Lim

Sungsu Lim

Seok Kyu Kim

Hyun-bin Kim

Hye Yeon Lee

Provided are a red fluorescent protein-based biosensor for measuring the activity of dopamine receptor D1, a method of measuring the activity of dopamine receptor D1 using the biosensor, and a method of detecting a ligand binding to dopamine receptor D1.

Red fluorescent protein-based biosensor for measuring activity of dopamine receptor D1

Azepine derivatives acting on 5-HTreceptors and pharmaceutically acceptable salts thereof are disclosed. The azepine derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for and high antagonistic activities on 5-HTreceptors. Due to these advantages, the azepine derivatives and the pharmaceutically acceptable salts thereof can be applied to therapeutic or prophylactic agents for central nervous system diseases, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, biorhythm dysregulation, sleep disturbance, and smooth muscle diseases where 5-HTreceptors antagonistic activity is required.

Azepine derivatives as 5-HTreceptor modulators

Growing community of inventors

Seoul, South Korea

Jihye Seong