Pfizer Corporation

Agouron Pharmaceuticals, Inc.

Pfizer Products Inc.

Jihong Lou

Mingying He

Ru Zhou

Robert Steven Kania

William Henry Romines, Iii

Stephan James Cripps

Cynthia Louise Palmer

Seiji Nukui

Michael Raymond Collins

Judith Gail Deal

Jeffrey Allen Pfefferkorn

Meihua Mike Tu

Hao Bai

Simon Bailey

Dilip Ramakant Bhumralkar

Anthony Lai Ling

John William Benbow

Feng C Bi

Fengli Guo

Paul Stuart Humphries

Feng Bi

The present invention provides Formula (1A) compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. X, Y, Z, R, R, R, and Rare as described herein.

Substituted imidazoles useful for treating type II diabetes

The present invention relates to a compound of formula (I):  or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of:  Ring A, ring B, ring C, R, R, R, R, R, L, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).

Fused phenyl amido heterocyclic compounds

Substituted imidazole propanamide glucokinase activators

The invention relates to compounds represented by Formula (I): and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein each of X&#x2013;Xand R&#x2013;Rare defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).

Thienopyridine-phenylacetamides and their derivatives useful as new anti-angiogenic agents

The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, Rand R, R, R, and Rare as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.

Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use

The invention relates to compounds represented by the formula Iand to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, Rand R, R, R, and Rare as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.

Indolyl-urea derivatives of thienopyridines useful as antiangiogenic agents, and methods for their use

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San Diego, CA, United States of America

Jihong Lou