Empire Technology Development LLC

Shanghai Jiaotong University

Jihong Huang

Lu Wang

Jing Sun

Fan Zhao

Fujun Wang

Kun Sun

Yanan Lu

Sun Chen

Ziyi Lv

Kai Bai

Xihui Zhou

Xinjian Kou

A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: S1: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.

Preparation method of absorbable vascular stent coating for angiostenosis in infant

Disclosed herein are composites capable of self-repairing. In some examples, the composites include a binding medium and a plurality of binding medium-repairing particles. The binding medium-repairing particles disclosed herein comprise a reactive agent encapsulated in a shell, where the reactive agent can interact with the binding medium to form an aggregate in the presence of an aqueous medium. Also disclosed herein are methods for making the composites and methods for making the binding medium-repairing particles.

Self-repairing composites responsive in the presence of an aqueous medium

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Shanghai, China

Jihong Huang