Hutchison Medipharma Enterprises Limited

Nutrition Science Partners Limited

Jifeng Duan

Xiaoqiang Yan

Weihan Zhang

Yu Cai

Tao Wang

Wei-Guo Su

Yumin Cui

Yongxin Ren

Zhiming Ma

Hong Jia

Yang Sai

Weiguo Su

A compound of the following formula: wherein R, R, R, R4, R5, T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.

Pyrimidine derivatives

An extract ofextract containing andrographolide, 14-deoxyandrographolide, 14-deoxy-11,12-dehydroandrographolide, neoandrographolide, polysacchorides, and flavanoids. Also disclosed is a pharmaceutical composition containing such an extract and its use for treating inflammatory bowel disease.

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Quinazoline derivatives of the following formula: wherein R, R, R, R, R, R, R, R, R, R, X, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder with one of these compounds.

Use of substituted quinazoline compounds in treating age-related macular degeneration

Use of substituted quinazoline compounds in treating angiogenesis-related diseases

This invention relates to a method of inhibiting TNF&#x3b1; or IL-1&#x3b2; expression with an extract of Andrographis paniculata. The extract contains andrographolide, 14-deoxy-andrographolide, 14-deoxy-11,12-dehydrogen-andrographolide, and neoandrographolide.

Crude extracts from

Crude extracts from andrographis paniculata

This invention relates to a compound of the following formula: wherein R, R, R, G, and Z are defined herein. It also relates to is methods of treating autoimmune disease, cancer, and atherosclerosis with such a compound.

Decahydronaphthalene compounds

Substituted quinazoline compounds of the following formula: wherein R, R, R, R, R, R, R, R, R, R, and X are defined herein. It also discloses a pharmaceutical composition containing one of these compounds.

Substituted quinazoline compounds and their use in treating angiogenesis-related diseases

Disclosed are methods for inhibiting TNF&#x3b1; expression, IL-1&#x3b2; expression, iNOS expression, and NF-&#x3ba;B activity and methods for treating autoimmune disease, cancer, or atherosclerosis with a compound of the following formula: 

Costunolide derivatives

A compound of the following formula: wherein X, Y, and Z are as defined herein. Also disclosed are methods for inhibiting TNF&#x3b1; expression, IL-1&#x3b2; expression, iNOS expression, and NF-&#x3ba;B activity and methods for treating autoimmune disease, cancer, or atherosclerosis with such a compound.

This invention relates to a method of inhibiting TNF&#x3b1; or IL-1&#x3b2; expression with an extract ofThe extract contains andrographolide, 14-deoxy-andrographolide, 14-deoxy-11,12-dehydrogen-andrographolide, and neoandrographolide.

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Shanghai, China

Jifeng Duan