Guangzhou Cellprotek Pharmaceutical Co., Ltd

Guangzhou Cellprotek Pharmaceutical Ltd.

Jiesi Chen

Guangmei Yan

Jingxia Zhang

Pengxin Qiu

Haiyan Hu

Wei Yin

Wenbo Zhu

Bingzheng Lu

Yijun Huang

Jiayu Huang

Tiandong Leng

Hanfei Sang

Shujia Zhou

Xiuhua You

Chunhui Huang

Use of 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol and analogs thereof in the preparation of a drug for the prophylaxis or treatment of an altitude sickness caused by hypobaric hypoxia is provided, so as to provide a new drug for the prophylaxis or treatment of an altitude sickness. Researches revealed that 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol treatment can effectively reduce vasogenic edema of brain tissue ofcaused by hypobaric hypoxia, reduce the increased cerebral water content, and protect from neuronal vacuolar degeneration caused by hypobaric hypoxia, therefore it can improve neurological dysfunctions caused by hypobaric hypoxia and is useful in prophylaxis or treatment of an altitude sickness.

Neuro-protective agents and uses thereof

Disclosed is the use of 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol in preparing neuroprotective drugs. The compound has significant protective effect against neuron injuries caused by cerebral ischemia, spinal cord ischemia or hypoxia and has no obvious toxic reaction within effective dose thereof.

Use of 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol in preparation of neuroprotective drugs

Disclosed is the use of 5&#x3b1;-androstane(alkyl)-3&#x3b2;,5,6&#x3b2;-triol in preparing neuroprotective drugs. The compound has significant protective effect against neuron injuries caused by cerebral ischemia, spinal cord ischemia or hypoxia and has no obvious toxic reaction within effective dose thereof.

Use of 5&#x3b1;-androstane (alkyl)-3&#x3b2;,5,6&#x3b2;-triol in preparation of neuroprotective drugs

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Guangzhou, China

Jiesi Chen