Beijing Center for Disease Prevention and Control

Beijing Inno Medicine Co., Ltd.

Jiefang Sun

Lei Zhang

Qian Ma

Bing Shao

A cerasome delivery system for targeting activated cd44 molecule, a preparation method and use thereof: a surface of a cerasome is partially modified by a targeting ligand, the targeting ligand being a ligand which may specifically bind to an activated cd44 molecule. The cerasome delivery system may be used for the diagnosis, prevention and treatment of vulnerable plaque or diseases associated with vulnerable plaque.

Cerasome delivery system for targeting activated CD44 molecule, preparation method and use thereof

The present disclosure discloses a gold/quantum dot nanoprobe for detecting active ricin in a complex matrix and application thereof. The gold/quantum dot nanoprobe is a nanoprobe formed by utilizing gold nanoparticles and quantum dots, which are modified by single strand oligodeoxynucleotides (ssODN), to form double strand oligodeoxynucleotides in a base pairing hybridizing mode and assembling the gold nanoparticles and the quantum dots into a core-satellite structure. According to the present disclosure, the gold/quantum dot nanoprobe is used for detecting the active ricin, has a limit of detection of 7.46 ng/mL, is high in accuracy and good in reliability, and does not require large-scale equipment and complex operations. In order to further eliminate the false positive result, the present disclosure further provides a method for enriching ricin in a complex sample by utilizing magnetic beads. In a case that specific active ricin concentration does not need to be known, the gold/quantum dot nanoprobe provided by the present disclosure can implement naked eye visual detection by the quenched and switch-on operations of fluorescence.

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Beijing, China

Jiefang Sun