Shenyang Sinochem Agrochemicals R&d Co., Ltd.

Dalian Medical University

Jie Zhao

Wanqin Zhang

Shao Li

Changling Liu

Zhinian Li

Hongfei Wu

Aiying Guan

Lixin Zhang

Yuquan Song

Qin Sun

Jingbo Xu

Jie Lan

Xufeng Sun

Xueming Cheng

Lizeng Wang

Jinbo Zhang

Liang Chen

Sen Ma

Keke Li

Junli Liu

Xuanming Chen

Lijun Ru

KeKe Li

A scorpion venom heat-resistant synthetic peptide (SVHRSP) contains an amino acid sequence of SEQ ID NO 1. One or more amino acids the amino acid sequence can be substituted or deleted. A pharmaceutical composition that contains the SVHRSP has numerous applications. The pharmaceutical composition can be used to protect neuronal cell against amyloid beta-induced toxic effects, or to inhibit the sodium channel current of a hippocampal neuronal cell, or to protect a neuronal cell against NMDA-induced injury. It may also promote the formation of a pluripotent neural stem cell from a type II astrocyte, or treats a subject, such as a human, having epilepsy, Alzheimer's disease, or Parkinson's disease.

Methods of reducing neuronal injury or toxicity in epilepsy, Alzheimer's disease or Parkinson's disease using a scorpion venom heat-resistant synthetic peptide (SVHRSP)

Disclosed is a malononitrile oxime ether compound having a novel structure as shown in the general formula I. Respective substituents in the general formula I as defined in the specification.  The compound of the general formula I exhibits an excellent microbicidal activity, and can effectively prevent and treat plant diseases caused by bacteria and fungi. Also provided is a use of the compound of the general formula I as a microbicide in the agricultural and other fields.

Malononitrile oxime ether compound and use thereof

A scorpion venom heat-resistant synthetic peptide (SVHRSP) contains an amino acid sequence of SEQ ID NO 1. One or more amino acids the amino acid sequence can be substituted or deleted. A pharmaceutical composition that contains the SVHRSP has numerous applications. The pharmaceutical composition can be used to protect neuronal cell against amyloid beta-induced toxic effects, or to inhibit the sodium channel current of a hippocampal neuronal cell, or to protect a neuronal cell against NMDA-induced injury. It may also promotes the formation of a pluripotent neural stem cell from a type II astrocyte, or treats a subject, such as a human, having epilepsy, Alzheimer's disease, or Parkinson's disease.

Scorpion venom heat-resistant synthetic peptide and applications thereof

Disclosed are pyrazolyl pyrimidinamine compounds with structures as shown in Formula I:  The definitions of each of the substituents can be seen in the description. The compounds of present invention have a broad spectrum of bactericidal, insecticidal and acaricidal activity, and have good control effect on downy mildew of cucumber, powdery mildew of wheat, corn rust, anthracnosis of cucumber and the like, and especially have better control effect on downy mildew of cucumber, powdery mildew of wheat and anthracnosis of cucumber. The compounds of present invention also show good insecticidal activity, part of the compounds, at very low doses, have excellent control effect on diseases caused by, armyworm,etc.

Pyrazolyl pyrimidinamine compound and application thereof

Growing community of inventors

Liaoning, China

Jie Zhao