Sichuan Jiuzhang Biological Science and Technology Co., Ltd.

Southwest Petroleum University

Chengdu University of Technology

University of Electronic Science and Technology of China

Chengdu University of Information Technology

Meishan Crrc Brake Science & Technology Co., Ltd.

Chengdu Accsoon Technology Co., Ltd.

Chimagen Biosciences, Ltd.

Sichu Jiuzhang Boplogical Science and Technology Co., Ltd.

Sichuan Jiuzhang Bio-Technology Co., Ltd.

Jie Zhang

Wang Huang

Xiaoguang Chen

Huarong Yang

Lina Zhu

Liang Zhang

Wei Jiang

Xin Li

Xuefeng Sun

Xuehua Chen

Cuinan Li

Xin Luo

Xianjie He

Qiang Wei

Zhilin Li

Weilin Chen

Chenxu Tian

Yongjiang Yan

Mengtian Zhang

Ya Zhang

Peigang Wang

Jie Li

Yuhua Cheng

Chun Yin

Fei Zhang

Libing Bai

Lin Chen

Fan Yang

Hong An

Lei Xie

Yanfei Shen

Yu Zhu

Qiaoyin Li

Binyong Li

Xianhui Deng

Ling Ning

Yonggang Wang

Jiheng Wu

Jing Zhang

Wenqing Ye

Zhenhao Zhou

Xiaoqing Wang

Yong Jiang

Qiulai Xue

Mubai Duan

Liangming Deng

Wenbin Li

Shuaishuai Jiang

Bingnan Lv

He Xu

Zaipeng Zhao

Jingbin He

Xiaoxiao Du

Nina Xue

Chen Zhou

Wei Xiang

Shuai Shi

Xue Chen

Jun Huang

Yazhuo Zhang

Shaowei Zhang

Wen-Bin Li

Chlorogenic acid is used in the preparation of a drug for treating and/or preventing ocular inflammation. Chlorogenic acid can significantly alleviate symptoms of uveitis and scleritis, and has good treatment effects on ocular inflammation.

Use of chlorogenic acid in preparation of drug for preventing and treating ocular inflammation

Disclosed is an experimental device and method for solubility determination of methane in oil-based drilling fluid, comprising a pressure-resistant gas chamber and an equilibrium still both arranged in a constant-temperature oil bath heating oven, a gas booster pump, and a vacuum system used for vacuuming the pressure-resistant gas chamber and the equilibrium still, and a data acquisition device for collecting temperature and pressure signals; the gas booster pump is connected to drive air source inlet, a gas check valve is arranged on the pipe between the pressure-resistant gas chamber and the gas booster pump that is also connected with a high-pressure gas cylinder, the equilibrium still is divided into a dissolution equilibrium chamber at the top and a hydraulic oil chamber at the bottom by a high-pressure dynamic seal structure, the dissolution equilibrium chamber is connected to a liquid inlet funnel through the fourth globe valve.

Experimental device and method for solubility determination of methane in oil-based drilling fluid

Chlorogenic acid and/or coumaroylquinic acid are employed in preparation of drugs for treating squamous cell carcinoma. Chlorogenic acid or coumaroylquinic acid can effectively treat squamous cell carcinoma. A combination of chlorogenic acid and coumaroylquinic acid can also achieve effective treatment, can yield a synergistic effect, and has excellent application prospect.

Application of chlorogenic acid and compositions thereof in preparation of drugs for treating squamous cell carcinoma

A pharmaceutical composition includes chlorogenic acid and coumaroylquinic acid. It can be used for preparing a reversing agent for tumor multi-drug resistance and a PD-1/PD-L1 inhibitor. The combined use of chlorogenic acid and coumaroylquinic acid exhibits a synergistic effect, effectuating a good reversing effect on the drug resistance of a tumor cell strain that produces multi-drug resistance for chemotherapeutic drugs and immunotherapeutic drugs, which may effectively inhibit PD-1/PD-L1 expression in drug-resistant B16 melanoma and drug-resistant Lewis lung cancer mice transplantation tumor tissue, and may effectively proliferate CD4+T and CD8+T cells in drug-resistant B16 melanoma mice and Lewis lung cancer mice.

Pharmaceutical composition and use thereof in preparing drug for treating tumor multi-drug resistance

A system for releasing the heavy-haul train has a control valve mounted in each of train cars. The control valve is connected to a train pipe, an auxiliary air reservoir and a brake cylinder are connected to the control valve, and an exhaust port is configured on the control valve. The exhaust port is connected to a solenoid valve. The method for improving the release performance of the heavy-haul train includes: S1: the solenoid valve in each of the train cars is powered on to close a passage between the exhaust port of the control valve and the atmosphere; S2: an automatic brake valve is regulated to inflate the train pipe; and S3: the solenoid valve in each of the train cars is powered off to open the passage between the exhaust port of the control valve and the atmosphere, so that the train is released.

System and method for improving release performance of heavy-haul train

A pharmaceutical composition contains chlorogenic acid and coumaroyl quinic acid. The combined use of chlorogenic acid and coumaroyl quinic acid at a certain ratio can generate a synergistic enhancing effect to effectively inhibit the growth of human kidney cancer cell strain A479, rat kidney cell strain RuCa, and rat transplanted tumor RuCa, providing a novel choice for clinical treatment of kidney cancer and having good market application prospects.

Pharmaceutical composition for treating kidney cancer and application thereof

Chlorogenic acid or compositions containing chlorogenic acid are used in preparation of a medicament for treating sarcoma. The chlorogenic acid composition includes chlorogenic acid and coumaroyl quinic acid, can effectively treat sarcoma, and has a better therapeutic effect than the chemotherapeutic medicament doxorubicin. The experimental results show that the combination of chlorogenic acid and coumaroylquinic acid can have a synergistic effect.

Use of chlorogenic acid composition thereof in preparation of medicament for treating sarcoma

Disclosed herein are novel bispecific and tri-specific antibodies with increased stability and use thereof for therapy.

Covalent multi-specific antibody

Disclosed is a data transmission system having a transmitter and a receiver. The transmitter encodes external input signals to acquire coded transmission data transmitted in multiple paths with different frequency band, and then transmits them to respective receiver; and the receiver performs data fusion on the received transmission signals to acquire coded received data, and decodes it to acquire and output the decoded data. In conclusion, since the received signals are split into a plurality of transmission signals of different frequency bands by the transmitter and the signals are fused in the receiver, the signals are not susceptible to the same frequency interference during transmission, improving the anti-interference of the data transmission system, realizing high-reliability transmission at low cost or in a complex wireless environment, also expanding the applications of the data transmission system.

Data transmission system and data transmission method

The invention discloses an experimental system and a method for wellbore pressure testing under the coexistence of gas-kick and loss-circulation, comprising a drill string simulator, a wellbore simulator and a complex stratigraphic structure simulator communicated in sequence from top to bottom; further comprising a medium return pipeline for collecting the returning test liquid and a medium leakage module for collecting the leaking test liquid; further comprising a data acquisition system for collecting data during testing. In the present invention, the experimental system has a simple structure, and the experimental method can comprehensively cover the three stages of circulating, well shut-in and well killing during the occurrence of coexistence of gas-kick and loss-circulation, multiple groups of experiments can be conducted by changing a single variable at the same stage, thus making the experimental test results applicable to all stages of wellbore pressure control in drilling operation.

Experimental system and a method for wellbore pressure testing under the coexistence of gas-kick and loss-circulation

A data access processing method for an industrial Internet cloud service platform, comprising an industrial device with data to be accessed transmits a data access request to a data processing unit of the platform, and meanwhile uploads a device identifier capable of identifying the industrial device with data to be accessed, the data processing unit retrieves a data upload authentication tag matching the data to be accessed from a traceability unit according to the data access request, and a corresponding access strategy is selected for processing according to the data upload authentication tag, device representation, and the data access request. The data to be accessed can be processed flexibly and intelligently according to requirements of a data owner and an actual operation condition of the platform; and during data processing, various resources of the platform can be well regulated and controlled to process the data to be accessed.

Data access processing method for industrial internet cloud service platform

A medicine for combined use in cancer treatment, comprising chlorogenic acid and a hormone drug which have unit preparations of the same or different specifications and which are administered either together or separately, as well as comprising a pharmaceutically acceptable carrier. The combined use of the chlorogenic acid and hormone drug achieves the effects of synergistic interaction, which thus overcome the defects of single drug treatment, such as a major toxic side effect and a poor treatment outcome and may reverse the drug resistance to hormone drugs and has good prospects for clinical application.

Medicine for combined use in cancer treatment

An anti-tumor composition for nasal administration has chlorogenic acid as an active ingredient, with the addition of pharmaceutically acceptable excipients or auxiliary ingredients. The chlorogenic acid preparation can improve the bioavailability of chlorogenic acid for nasal administration, penetrate the blood-brain barrier, have a significant inhibitory effect on brain tumors and nasopharyngeal carcinoma, and possess a clinical application value.

Chlorogenic acid-containing composition for nasal administration

A drug that contains chlorogenic acid is effective in treating chordoma. When administered to a patient in need thereof, chlorogenic acid can significantly inhibit the proliferation of chordoma cells, reduce the expression level of multi-drug resistance gene MDR1 of chordoma cells, reverse the multi-drug resistance of chordoma cells, and effectively treat chordoma disease.

Use of chlorogenic acid in preparation of drug for treating chordoma

A drug combination for treatment of amyotrophic lateral sclerosis includes chlorogenic acid, vitamin E, vitamin C, coenzyme Q10, and creatine phosphate sodium, as well as pharmaceutically acceptable carriers, in which chlorogenic acid, vitamin E, vitamin C, coenzyme Q10, and creatine phosphate sodium are unit preparations having same or different specifications, that are simultaneously or separately administrated. The combination of chlorogenic acid, vitamin E, vitamin C, coenzyme Q10, and creatine phosphate sodium shows a synergistic effect on amyotrophic lateral sclerosis, thus provides a combination with excellent therapeutic effect on amyotrophic lateral sclerosis, which delays the progression of amyotrophic lateral sclerosis.

Drug combination for treatment of amyotrophic lateral sclerosis, preparation method and use thereof

Growing community of inventors

Sichuan, China

Jie Zhang