Arizona State University

The United States of America, as Represented by the Secretary, Department of Health and Human Services

University of Illinois

Jie Wang

Joshua LaBaer

Ji Qiu

Karen Anderson

Garrick Wallstrom

Jin Park

Brian Kay

Kevin Gorman

Jonine Figueroa

Ji Qui

Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

Plasma autoantibody biomarkers for basal like breast cancer

Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.

Generating recombinant affinity reagents with arrayed targets

Growing community of inventors

Tempe, AZ, United States of America

Jie Wang