Aeroquip Corporation

University of Michigan

Jie Tang

Gary B Hess

Mark D Muszynski

Thomas S Goehring

Steven Paul Schwendeman

The disclosure relates to microspheres comprising a core and a shell. More particularly the disclosure relates to microspheres for extended, controlled release of a poorly water-soluble therapeutic agent having a solubility in water of 50 μg/mL or less, the microsphere having a core comprising the therapeutic agent, and a substantially impermeable shell surrounding the core. Methods of making and using the microspheres are also provided.

Microspheres for extended, controlled release of therapeutic agents

Uniform sized and shaped spheres are formed by applying a minute periodic disturbance to a low viscosity liquid material. Pressure forces the material through at least one orifice in a crucible as a steady laminar stream. The stream enters an enclosed controlled temperature solidification environment which contains at least one heat transfer medium. A charging means is applied to the stream as the stream exits the crucible and breaks into a plurality of spheres to deflect the spheres as they pass through an electric field. The enclosed controlled temperature solidification environment cools and substantially solidifies the spheres.

Apparatus and method for making uniformly sized and shaped spheres

Apparatus and method for making uniformly

Growing community of inventors

Ann Arbor, MI, United States of America

Jie Tang