Ngm Biopharmaceuticals, Inc.

Amgen Inc.

Other

Jie Tang

Kenneth William Walker

Gunasekaran Kannan

Agnes Eva Hamburger

Jackie Zeqi Sheng

Zhulun Wang

Yi Lin Zhang

Xiaoshan Min

Yan Wang

Murielle M Veniant-Ellison

YuMei Xiong

Grant Shimamoto

Wenyan Shen

Bryan D Lemon

Hugo Matern

Wenwu Zhai

Zhonghao Liu

Yiyuan Yin

Marissa Mock

Yi Zhang

Dana Yen Mei Duey

Jared Martin Higbee

Yumei Xiong

The present disclosure provides binding proteins, such as antibodies, that bind to a GDNF Family Receptor Alpha Like (GFRAL) protein, including human GFRAL protein, and methods of their use.

Binding proteins and methods of use thereof

The present disclosure provides binding agents, such as antibodies (including single chain variable fragments), that specifically bind complement component C3, including human C3, compositions comprising same, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising same.

C3-binding agents and methods of use thereof

GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Growth differentiation factor 15 (GDF-15) polypeptides

Anti-C3 antibodies

Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Growth differentiation factor 15 (GDF-15) constructs

Growing community of inventors

Palo Alto, CA, United States of America

Jie Tang