Chongqing Pharmaceutical Research Institute Co., Ltd

Chongqing University of Arts and Sciences

Jie Luo

Jie Deng

Wenrun Ye

Meng Lin

Bo Lin

Yongmei Qin

Zhongzhu Chen

Dianyong Tang

Zhigang Xu

Jie Lei

Dandan Xia

Huafu Sun

Jiayu Xu

Yao Liu

Chunyan Dan

Bin Fan

Haoyi Zhou

Zhengyong Zhu

Junlai Luo

Yihua Cao

The present application relates to processes for the preparation of quinolone compounds and intermediates thereof, particularly to processes for the preparation of quinolones and pharmaceutical intermediates of the quinolones. In particular, the present application provides a process for the preparation of a compound of Formula I, and a process for the synthesis of quinolone compounds using the compound of Formula I as an intermediate. The process for the preparation of the compound of Formula I comprises the steps of:

Preparation methods of quinolone compounds and intermediates thereof

A method of purifying a salt of pemetrexed having a structure of formula (III) by salting-out, wherein if Mis H, then each of Mand Mis independently H, Li, Naor K, provided that both of them are not H; if Mis Li, Naor K, then each of Mand Mis independently Li, Naor K. 

Method of purifying a salt, sodium salt and disodium salt of pemetrexed

The present invention relates to morphinan derivatives and preparation methods thereof, especially to ketal hydroxyl protected compounds of morphinan derivatives and preparation method thereof, and to a method for preparing corresponding alkylated morphinan derivatives by using the ketal hydroxyl protected compounds as intermediates, and more especially to a ketal hydroxyl protected compound of methylnaltrexone as intermediate for preparing methylnaltrexone and a method for preparing methylnaltrexone through said intermediate.

Morphinan derivatives and preparation methods thereof

Three new crystalline forms of pemetrexed diacid, preparation methods and uses thereof are disclosed. These preparation processes are simple and have better practicality.

Crystalline forms of Pemetrexed diacid, and preparations thereof

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Chongqing, China

Jie Luo