Beijing Normal University

Shanghai United Imaging Healthcare Co., Ltd.

Beijing Jingdong Qianshi Technology Co., Ltd.

Beijing Shihong Pharmaceutical Research Center

Beijing Baidu Netcom Science Technology Co., Ltd

Jie Lu

Junbo Zhang

Xuebin Wang

Zhigang Tang

Zhanbin Zhang

Qing Ruan

Xuran Zhang

Qianqian Gan

Hui Liu

Qiang He

Yuhang Shi

Keyao Wang

Xin Shao

Guoguang Zhao

Yuhao Jiang

Haocheng Feng

Haixiao Yue

Qianna Wang

Guangxing Yin

Jun'an Zheng

Yunhao Li

A mannose derivative is an isonitrile-containing mannose derivative of formula (I), including different linking groups X: A radioactive preparation is provided, including a radiolabeled compound formed by radiolabeling the mannose derivative with a radionuclide. An application of the radioactive preparation in the diagnosis and treatment of tumors is also provided.

Mannose derivative and application thereof

Disclosed herein is a benzene ring-containing glucose derivative of formula (I): where Ris each independently and Ris hydrogen. This application also provides a radioactive drug, including a complex formed by the benzene ring-containing glucose derivative and a radionuclide. Use of the benzene ring-containing glucose derivative in the tumor treatment and diagnosis is further provided.

Benzene ring-containing glucose derivative and use thereof

ATc-labeled isonitrile-containing glucose derivative having the general formula [Tc-(CNDG)], preparation method and use thereof is disclosed herein. The derivative is centered onTc, and the carbon atom of the isonitrile in CNDG coordinates withTc(I) to form a hexacoordinated complex [Tc-(CNDG)]. The [Tc-(CNDG)]derivative was obtained by the synthesis of the ligand CNDG and the preparation of the lyophilized CNDG kit. The derivative of this disclosure has good stability, simple preparation, high uptake and good retention at a tumor site, and high tumor/non-target ratio, and it is a novelTc-labeled isonitrile-containing glucose derivative with excellent performance for tumor imaging. The derivative of this disclosure is advantageous for popularization and application.

Tc-labeled isonitrile-containing glucose derivative and preparation method and use thereof

Disclosed are a method and device for determining a driving route of a sorting robot. The method discloses: weighing and scanning on an import platform in response to a sorting robot, and determining a destination of the sorting robot on a sorting map; determining, according to the destination, a target package drop on the sorting map; identifying two dumping points on a route which is perpendicular to an import direction of the import platform among dumping points of the target package drop; respectively calculating the costs of routes from the import platform to the two dumping points; determining the dumping point corresponding to the smaller cost of route to be the target dumping point on the sorting map; determining a preferred package drop route from predetermined package drop routes to be selected from the import platform to the target dumping point; and sending a package drop task including the preferred package drop route to the sorting robot. Further disclosed are a method and device for determining a driving route of a sorting robot. The method and device improve the sorting efficiency of a sorting robot in a warehouse.

Method and device for determining driving route of sorting robot

The present disclosure relates to systems and methods for determining a motion of an object during imaging. The systems and methods may cause a light emission device to project a structured light onto the object, and cause a light reception device to detect light resulting from the structured light as projected onto the object and generate a plurality of measured images of the structured light based on the detected light. The systems and methods may further determine the motion of the object based on the plurality of measured images of the structured light and a reference image of the structured light.

Systems and methods for determining motion of an object in imaging

Growing community of inventors

Beijing, China

Jie Lu