University of California

Jie Liu

Nagichettiar Satyamurthy

Jorge R Barrio

Yang Yang

Liping Ma

A method of manufacturing 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)-malononitrile ([F-18]FDDNP) utilizes a semi-automated module that is used to perform fluorination, pre-purification, separation, product extraction, and formulation. The method is able to produce [F-18]FDDNP with high yields and ready for human administration under existing FDA regulations, and without the need for hazardous organic solvents such as dichloromethane (DCM), methanol (MeOH), and tetrahydrofuran (THF). The method also improves the speed with which [F-18]FDDNP can be synthesized with the method being able to generate a final product within about 90 to 100 minutes. This synthesis method is easily adaptable to FDA registered and approved automated synthesis systems.

Methods for multi-dose synthesis of [F-18]FDDNP for clinical settings

A bistable electrical device () employing a bistable body () and a high conductivity material (). A sufficient amount of high conductivity material () is included in the bistable body () to impart bistable between a low resistance state and a high resistance state by application of an electrical voltage ().

Growing community of inventors

Alhambra, CA, United States of America

Jie Liu