Allied Bioscience, Inc.

Srfc Bio, Inc.

Jie Fang

Gavri Grossman

Craig Grossman

Maha El-Sayed

Parham Asgari

Daniel A Moros

Misagh Alipour

Valerie Beck

Elias Shaheen

Daniel Moros

The present disclosure provides antimicrobial coating compositions that are used to form residual antimicrobial coatings on medical implements and medical devices including the components of medical equipment such as CPAP/BiPAP machines. Antimicrobial coating compositions comprise at least one of an organosilane (RO)Si&#x2014;R&#x2014;Z, an organic amine RRRN, a titanium (IV) species, a 1,2-diol, an &#x3b1;-hydroxy acid, a &#x3b2;-hydroxy acid, and an organosilane grafted parylene polymer, wherein Ris H, alkyl, substituted alkyl, aryl or substituted aryl, Ris a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R, R, and Rare independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

Antimicrobial coatings for medical implements and medical devices

A method of quantifying an antimicrobial coatings using a handheld XRF analyzer is disclosed. The method provides an estimate of the expected level of antimicrobial efficacy for a thin film comprising silicon and/or titanium by obtaining aSi orTi peak intensity using XRF spectroscopy and converting the obtainedSi orTi peak intensity to the expected level of efficacy using a calibration curve. A properly calibrated handheld XRF analyzer allows a user to assess the viability of antimicrobial coatings in the field, such as in a hospital where various fomites may be coated with silane and/or titanium compositions.

Analysis of antimicrobial coatings using XRF

Aqueous antimicrobial coating compositions are disclosed comprising at least one organosilane homopolymer, present as a distribution of polymer chain lengths, and optionally at least one amine. A method of preparing an antimicrobial coating comprises coating a surface with the aqueous antimicrobial coating composition and allowing the composition to dry into a film that exhibits residual antimicrobial efficacy against microorganisms even after mechanical abrasion of the coating. The organosilane homopolymer may comprise only 3-aminopropylsilanetriol homopolymer, mixtures of 3-aminopropylsilanetriol homopolymer, 3-chloropropylsilanetriol homopolymer and 3-(trihydroxysilyl)propyl dimethyloctadecyl ammonium chloride homopolymer, or any one of various unique organosilane homopolymers having multiple amine functionality.

Antimicrobial coatings comprising organosilane homopolymers

A wet wipe is disclosed that provides both contact sanitization of a surface and application of a residual antimicrobial coating on the surface through the same wiping. The wet wipe comprises a substrate such as an absorbent nonwoven fabric and a liquid composition impregnated therein, the liquid composition comprising an organosilane such as the antimicrobial dimethyloctadecyl[3-(trimethoxysilyl)propyl] ammonium chloride, a non-silane quaternary disinfectant, an organic amine, and a solvent. The non-silane quaternary actives comprise a mixture of actives, and the solvent comprises 60 wt. % isopropanol or more.

Wet wipes comprising antimicrobial coating compositions

The present disclosure provides antimicrobial coating compositions that are used to form residual antimicrobial coatings on medical implements and medical devices including the components of medical equipment such as CPAP/BiPAP machines. Antimicrobial coating compositions comprise at least one of an organosilane (RO)Si&#x2014;R&#x2014;Z, an organic amine RRRN, a titanium (IV) species, a 1,2-diol, an &#x3b1;-hydroxy acid, &#x3b2;-hydroxy acid, and an organosilane grafted parylene polymer, wherein Ris H, alkyl, substituted alkyl, aryl or substituted aryl, Ris a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R, R, and Rare independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

An aqueous antimicrobial coating composition capable of forming an antimicrobial coating on a surface comprises at least two organosilanes, each of the at least two organosilanes having a structure, R&#x2014;Si(OR')wherein R=&#x2014;(CH)&#x2014;Y; Y=&#x2014;N(CH)(CH)X;&#x2014;N(CH)(CH)X;&#x2014;N(CH)(CH)X; &#x2014;Cl or &#x2014;NH; X=halide, sulfate, nitrate, phosphate, carbonate, organic sulfonate, organic carbonate, BF, or ClO; and R&#x2032;=H, methyl or ethyl, or a C-Cstraight-chained, branched or cyclic alkyl group, with the proviso that the organosilane R&#x2014;Si(OR&#x2032;)having the C-Cstraight-chained, branched or cyclic alkyl group hydrolyzes in the aqueous antimicrobial coating composition to R&#x2014;Si(OH).

Broad spectrum antimicrobial coatings comprising combinations of organosilanes

Antimicrobial coating compositions are used to form dried residual antimicrobial coatings on medical dressings including gauze, bandages, gowns and dry wipers. Antimicrobial coating compositions comprise at least one of an organosilane (RO)Si&#x2014;R&#x2014;Z, an organic amine RRRN a titanium (IV) species, a 1,2-diol, an &#x3b1;-hydroxy acid, a &#x3b2;-hydroxy acid, and an organosilane grafted parylene polymer, wherein Ris H, alkyl, substituted alkyl, aryl or substituted aryl, Ris a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent and R, R, and Rare independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

Antimicrobial coatings for medical dressings and dry antimicrobial medical dressings therefrom

A method of preparing an antimicrobial coating comprises coating a surface with an aqueous mixture of 3-(trihydroxysilyl)propyl dimethyloctadecyl ammonium chloride, 3-chloropropyltrimethoxysilane, and triethanolamine and then coating the surface with an aqueous titanyl sol-gel solution comprising an aqueous mixture of peroxotitanium acid and peroxo-modified anatase sol overtop of the silane to form the antimicrobial coating. The antimicrobial coating exhibits residual antimicrobial efficacy againstandafter water rinsing or after abrasion. The use of 3-chloropropyltrimethoxysilane was found to improve storage stability of the quaternary silane composition and the durability of the antimicrobial coating.

Growing community of inventors

Carrollton, TX, United States of America

Jie Fang