Cook Medical Technologies LLC

Med Institute Incorporated

Cook Biotech, Inc.

Cook Incorporated

Jichao Sun

Alan R Leewood

Neal E Fearnot

Lal Ninan

Clinton D Bahler

Blayne A Roeder

Thomas A Osborne

Steven Charlebois

William Kurt Dierking

Matthew S Huser

Michael P DeBruyne

David Douglas Grewe

James D Purdy

Jason A Mead

Jarin A Kratzberg

Keith Milner

Kenneth Aaron Haselby

Kurt Dierking

Brandt M Davis

Natalie M Abell

Steven J Charlebois

Kenneth Haselby

The present embodiments provide an endoluminal prosthesis, such as a stent-graft, having a relatively low delivery profile. In one embodiment, the prosthesis comprises a membrane, and at least one stent having contracted and expanded states, where the stent is coupled to the membrane and maintains patency in the expanded state. The prosthesis further may comprise selectively oriented axial and/or circumferential fibers arranged at predetermined locations along the length and circumference of the prosthesis. An increased population density of the circumferential and/or axial fibers may be provided in areas in which the at least one stent portion is attached to the membrane, or in areas of higher physiological loads imposed upon the endoluminal prosthesis. Selectively orienting axial fibers and circumferential fibers at predetermined locations along the length and circumference of the prosthesis, but not continuously along the entire prosthesis, significantly reduces delivery profile due to the reduction in graft material.

Medical prostheses having bundled and non-bundled regions

The technology described herein relates to a stent graft and a method of making the stent wherein the stent comprises interconnected struts and is connected to the graft material by applying at least one band of polymer so as to cover at least a portion of at least some of the struts. A stent supported area is created by the stent's attachment to the graft material and the at least one band of polymer is applied so as to leave the majority of the stent supported area uncovered by the at least one band of polymer.

Stent attachment for endovascular aneurysm repair

An aortic stent-graft may include a tubular graft extending from a proximal end to a distal end, the graft comprising a proximal sealing portion and an intermediate portion, wherein a proximal end of the intermediate portion abuts the distal end of the proximal sealing portion. At least one sealing stent may be attached to the proximal sealing portion. A first fenestration window is disposed in the intermediate portion. The first fenestration window has a length determined by the equation L=1.23*D&#x2212;24 millimeters, where L is the length of the first fenestration window. D is between about 24 millimeters and 45 millimeters.

Medical device delivery system and deployment method

A stent graft () has a tubular body of a biocompatible material and a side arm () fastened to the tubular body. A tubular extension piece () is sealingly joined to the end of the side arm and extends from it. It can be joined with adhesive or stitching. The extension piece can be formed from an elastomeric biocompatible material such as Thoralon&#x2122;. The extension piece can have a resilient reinforcementembedded into it and extending longitudinally. The extension piece is tucked back into the side arm during deployment of the stent graft into a body lumen.

Branch vessel stent graft

Methods for coating medical devices for implantation within a body vessel are provided comprising providing a cylindrical container, placing a medical device inside the cylindrical container, and applying a polymer in liquid form inside the container.

Medical device coating process

A method of making an endovascular prosthesis comprises the steps of applying a first layer of polymer to a portion of a deformable matrix, contacting a stent with the polymer to deform the matrix, applying a second layer of polymer over at least a portion of the stent and first layer, solidifying the layers of polymer to form the endovascular prosthesis, and removing the matrix.

Methods of making an endovascular prosthesis using a deformable matrix

This invention is directed to graft materials for implanting, transplanting, replacing, or repairing a part of a patient and to methods of making the graft materials. The present invention is also directed to stent grafts and endoluminal prostheses formed of the graft materials. More specifically, the present invention is a graft material which includes porous polymeric sheet, extracellular matrix material (ECM) disposed on at least a portion of the porous polymeric sheet and at least one polymer layer disposed on at least a portion of the ECM. The ECM may be in a gel form. The polymeric sheet and the polymer layer may be made from foam material and may comprise a polyurethane urea and a surface modifying agent such as siloxane.

Graft material, stent graft and method

An endoluminal device comprises a stent and a tubular graft supported by the stent. The graft has a proximal and a distal opening and comprises a synthetic material and a bioremodelable material. The bioremodelable material is disposed on an exterior surface in at least one band adjacent at least one of the proximal and distal openings.

Endoluminal device with extracellular matrix material and methods

The present invention relates to methods of treating tissue of the human body, specially, methods of promoting cell proliferation and ingrowth around implantable medical devices. The methods include inserting an apparatus comprising asperities adapted to injure native tissue at a desired anchoring location, injuring the native tissue at the desired anchoring location with the apparatus to initiate an injury response in the native tissue to thereby promote cell proliferation and ingrowth; and implanting the medical device at the treatment location.

Method of promoting cell proliferation and ingrowth by injury to the native tissue

A variable curvature stent limb is disclosed herein. A stent derived from a plurality of these variable curvature stent limbs may be highly compressible, such that it is compatible with a low-profile delivery device. This stent may be useful over a wider range of body vessel diameters and may possess a greater fatigue life, since this stent may provide a more controlled constant radial force.

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West Lafayette, IN, United States of America

Jichao Sun