University of California

The Scripps Research Institute

Irm LLC

Argusina Bioscience Inc.

Jiayu Liao

Peter G Schultz

Bin Liu

Sheng Ding

Yufeng Hong

Thomas W Von Geldern

Yan Liu

Yong Wang

Kanyin E Zhang

Yongfeng Zhao

Ke Shuai

Chan Chung

Xiaoping Rao

Yang Song

The disclosure provides method and composition utilizing fluorescent amino acids and endogenous fluorescent proteins comprising a moiety capable of undergoing FRET. The methods and compositions of the disclosure are useful in analyzing protein structure and function, and screening molecular inhibitors.

High-sensitive fluorescent energy transfer assay using fluoresent amino acids and fluorescent proteins

Provided herein are non-peptide GLP-1 receptor modulator compounds, for example, of Formula I, pharmaceutical compositions comprising such compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of a metabolic disorder. 

Phenylalanine derivatives and their use as non-peptide GLP-1 receptor modulators

This invention provides novel genes and polypeptides of the sweet receptor family, methods for production of the polypeptides, methods for screening compounds that specifically bind to and/or modulate the activity of these polypeptides; and antibodies specific for the polypeptides.

Sweet taste receptors

The invention provides a family of proteins named PIAS which function as specific inhibitors of STAT proteins. Methods of using PIAS molecules are also provided to regulate STAT proteins.

PIAS molecules that recognize and bind STAT proteins and uses thereof

Growing community of inventors

Carlsbad, CA, United States of America

Jiayu Liao