Biocytogen Pharmaceuticals (Beijing) Co., Ltd.

Biocytogen Jiangsu Co., Ltd.

Beijing Biocytogen Co., Ltd

Huawei Technologies Co., Limited

Biocytogen Pharmaceuticals Co., Ltd.

Jiawei Yao

Yuelei Shen

Yang Bai

Rui Huang

Yanan Guo

Meiling Zhang

Chaoshe Guo

Lei Zhao

Xiaofei Zhou

Chengzhang Shang

Hui Lu

Lili Liu

Chen Wang

Xing Wang

Yabo Zhang

Feng Peng

Feng Zhao

Huizhen Zhao

Shuwen Huang

Wenjie Wei

Hanyu Zhu

The present disclosure relates to the genetically modified non-human animals that have a disruption at the endogenous CD132 gene (e.g., CD132 knockout), and methods of use thereof

Immunodeficient non-human animal

The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD3e (T-cell surface glycoprotein CD3 epsilon chain), and methods of use thereof.

Genetically modified non-human animal with human or chimeric CD3e

The present disclosure relates to genetically modified animals and cells with humanized heavy chain immunoglobulin locus and/or humanized light chain immunoglobulin locus.

Genetically modified non-human animals with humanized immunoglobulin locus

This disclosure relates to genetically modified animals and cells with humanized light chain immunoglobulin locus and/or humanized heavy chain immunoglobulin locus. In one aspect, the endogenous light chain immunoglobulin locus comprises a limit number of human IGKV genes and human IGKJ genes.

Genetically modified non-human animals with common light chain immunoglobulin locus

The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) LAG3, and methods of use thereof.

Genetically modified non-human animal with human or chimeric LAG3

The present disclosure relates to the genetically modified non-human animals that express a human or chimeric OX40, and methods of use thereof.

Genetically modified non-human animal with human or chimeric OX40

The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD40, and methods of use thereof.

Genetically modified mice expressing humanized CD40

Provided are a humanized transgenic non-human animal, especially a rodent, in particular a transgenic mouse containing a human interleukin 17A (IL-17A) gene, a human gene 17RA (IL-17RA) and/or a human TNF-alpha gene, and a preparation method therefor and the use thereof.

Humanized transgenic animal

The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD28, and methods of use thereof.

Genetically modified non-human animal with human or chimeric CD28

The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) programmed cell death protein 1 (PD-1), and methods of use thereof. In one aspect, the animals have an insertion of a sequence encoding a human or humanized programmed cell death protein 1 (PD-1) at an endogenous PD-1 gene locus. This animal model can express a PD-1 protein containing a functional domain of the human PD-1 protein, and can be used as an animal model for developing therapeutics for human diseases and disorders, and assessing the toxicity and/or the efficacy of these human therapeutics.

Genetically modified non-human animal with human or chimeric PD-1

The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL15, and methods of use thereof.

Genetically modified non-human animal with human or chimeric IL15

The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD137, and methods of use thereof.

Genetically modified non-human animal with human or chimeric CD137

The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL4R and/or IL4, and methods of use thereof.

Growing community of inventors

Beijing, China

Jiawei Yao